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Keywords:

  • hereditary neoplastic syndromes;
  • prostate specific antigen (PSA);
  • age factors

Abstract

BACKGROUND

The decline in age at prostate cancer diagnosis over the past decade is partially attributable to prostate specific antigen (PSA) screening. We examined age at diagnosis over successive generations within prostate cancer families.

METHODS

Families with at least two affected men were selected from the University of Michigan Prostate Cancer Genetics Project. The 1,345 individuals from 489 families were grouped into three generations.

RESULTS

Risk of prostate cancer diagnosis at a given age was estimated to increase 1.31 (95% CI: 1.13–1.51) times from one generation to the next. Among men diagnosed prior to the PSA era, inferences were similar (hazard ratio = 1.28, 95% CI: 0.97–1.68). No maternal versus paternal disease transmission effect was observed.

CONCLUSIONS

Age at prostate cancer diagnosis was observed to decrease over successive generations in families from an ongoing familial prostate cancer study. This finding, if confirmed, may have important implications for familial prostate cancer risk assessment. © 2005 Wiley-Liss, Inc.