The North Carolina–Louisiana Prostate Cancer Project (PCaP): Methods and design of a multidisciplinary population-based cohort study of racial differences in prostate cancer outcomes

Authors

  • Jane C. Schroeder,

    1. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    2. Lineberger Comprehensive Cancer Center of the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
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  • Jeannette T. Bensen,

    Corresponding author
    1. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    2. Lineberger Comprehensive Cancer Center of the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    • University of North Carolina at Chapel Hill, UNC Lineberger Comprehensive Cancer Center-North, 1700 Airport Rd, CB # 7294, Chapel Hill, NC 27599-7294.
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  • L. Joseph Su,

    1. Louisiana State University Health Sciences Center, School of Public Health, Baton Rouge, Louisiana
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  • Merle Mishel,

    1. School of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
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  • Anastasia Ivanova,

    1. Lineberger Comprehensive Cancer Center of the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    2. Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
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  • Gary J. Smith,

    1. Department of Urologic Oncology, Roswell Park Cancer Institute, and University of Buffalo School of Medicine and Biotechnology, Buffalo, New York
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  • Paul A. Godley,

    1. Lineberger Comprehensive Cancer Center Program on Ethnicity, Culture, and Health Outcomes; and Division of Hematology/Oncology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
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  • Elizabeth T. H. Fontham,

    1. Louisiana State University Health Sciences Center, School of Public Health, Baton Rouge, Louisiana
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  • James L. Mohler

    1. Lineberger Comprehensive Cancer Center of the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    2. Department of Urologic Oncology, Roswell Park Cancer Institute, and University of Buffalo School of Medicine and Biotechnology, Buffalo, New York
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  • First authorship shared by Dr. Schroeder and Dr. Bensen.

Abstract

BACKGROUND

The North Carolina–Louisiana Prostate Cancer Project (PCaP) is a multidisciplinary study of social, individual, and tumor-level causes of racial differences in prostate cancer aggressiveness.

METHODS

A population-based sample of incident prostate cancer cases from North Carolina and Louisiana will include 1,000 African Americans and 1,000 Caucasian Americans. Study nurses administer structured questionnaires and collect blood, adipose tissue, urine, and toenail samples during an in-home visit. Clinical data are abstracted from medical records, diagnostic biopsies are reviewed and assayed, and tissue microarrays are constructed from prostatectomy samples. Prostate cancer aggressiveness is classified based on PSA, clinical stage, and Gleason grade.

RESULTS

Preliminary data demonstrate between- and within-group differences in patient characteristics, screening, and treatment by race and state. Participation exceeds 70% in all groups.

CONCLUSIONS

Preliminary data support the feasibility of this comprehensive study to help determine the focus of public health efforts to reduce racial disparities in prostate cancer mortality. Prostate © 2006 Wiley-Liss, Inc.

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