Disparities at presentation, diagnosis, treatment, and survival in African American men, affected by prostate cancer
Article first published online: 28 DEC 2010
Copyright © 2010 Wiley-Liss, Inc.
Volume 71, Issue 9, pages 985–997, 15 June 2011
How to Cite
Chornokur, G., Dalton, K., Borysova, M. E. and Kumar, N. B. (2011), Disparities at presentation, diagnosis, treatment, and survival in African American men, affected by prostate cancer. Prostate, 71: 985–997. doi: 10.1002/pros.21314
- Issue published online: 4 MAY 2011
- Article first published online: 28 DEC 2010
- Manuscript Accepted: 2 NOV 2010
- Manuscript Received: 12 AUG 2010
- National Institute of Health (NIH). Grant Number: 1 P20 MD003375-01
- prostate cancer;
- African American population;
- health disparities
Prostate cancer (PCa) remains the most common malignancy and the second leading cause of cancer death among men in the United States. PCa exhibits the most striking racial disparity, as African American men are at 1.4 times higher risk of being diagnosed, and 2–3 times higher risk of dying of PCa, compared to Caucasian men. The etiology of the disparity has not been clearly elucidated. The objective of this article is to critically review the literature and summarize the most prominent PCa racial disparities accompanied by proposed explanations.
The present literature on disparities at presentation, diagnosis, treatment, and survival of African American men affected by PCa was systematically reviewed. Original research as well as relevant review articles were included.
African American men persistently present with more advanced disease than Caucasian men, are administered different treatment regimens than Caucasian men, and have shorter progression-free survival following treatment. In addition, African American men report more treatment-related side-effects that translates to the diminished quality of life (QOL).
PCa racial disparity exists at stages of presentation, diagnosis, treatment regimens, and subsequent survival, and the QOL. The disparities are complex involving biological, socio-economic, and socio-cultural determinants. These mounting results highlight an urgent need for future clinical, scientific, and socio-cultural research involving transdisciplinary teams to elucidate the causes for PCa racial disparities. Prostate 71: 985–997, 2011. © 2010 Wiley-Liss, Inc.