Metabolic syndrome is associated with high grade gleason score when prostate cancer is diagnosed on biopsy
Article first published online: 25 FEB 2011
Copyright © 2011 Wiley-Liss, Inc.
Volume 71, Issue 14, pages 1492–1498, 1 October 2011
How to Cite
De Nunzio, C., Freedland, S. J., Miano, R., Trucchi, A., Cantiani, A., Carluccini, A. and Tubaro, A. (2011), Metabolic syndrome is associated with high grade gleason score when prostate cancer is diagnosed on biopsy. Prostate, 71: 1492–1498. doi: 10.1002/pros.21364
- Issue published online: 25 AUG 2011
- Article first published online: 25 FEB 2011
- Manuscript Accepted: 24 JAN 2011
- Manuscript Received: 26 NOV 2010
- prostate cancer;
- metabolic syndrome;
- needle biopsy;
- Gleason score
To evaluate the association between metabolic syndrome (MS) and prostate cancer diagnosis and grade in patients undergoing prostate biopsy.
From 2009 onwards, a consecutive series of patients undergoing 12-core prostate biopsy for PSA value ≥4 ng/ml and/or positive digital rectal examination (DRE) were prospectively enrolled. Body mass index (BMI), waist circumferences, and blood pressure were measured before the biopsy. Blood samples were tested for: PSA, fasting glucose, triglycerides, and cholesterol HDL. MS presence was defined according to Adult Treatment Panel III criteria.
One hundred ninety five patients were enrolled with a median age and PSA of 69 years and 5.6 ng/ml respectively. Median BMI was 27.6 kg/m2 with 64 patients (33%) being classified as obese (BMI ≥ 30 kg/m2). Eighty-six patients (44%) had MS. Eighty-three patients (43%) had cancer on biopsy; 37 (45%) with MS and 46 (55%) without (P = 0.48). PSA was independently associated with higher risk of cancer (OR 1.12/1 U PSA, P = 0.01). Out of 83 patients with prostate cancer, 42 (51%) had Gleason score 6 (12 (28.5%) presented a MS) and 41 (49%) a Gleason score ≥7 (25 (61%) presented a MS). The presence of MS was not associated with an increased risk prostate cancer (OR: 0.97, P = 0.94) but with an increased risk of Gleason ≥7 (OR: 3.82; P = 0.013).
In our single center study, MS is associated with an increased risk of high grade Gleason score when prostate cancer is diagnosed on biopsy. However, these results should be confirmed in a larger multicenter study. Prostate 71:1492–1498, 2011. © 2011 Wiley-Liss, Inc.