Zheng Lu and Yong Gao have contributed equally to this work and should be considered as co-first authors
Increased high-sensitivity c-reactive protein predicts a high risk of lower urinary tract symptoms in chinese male: Results from the fangchenggang area male health and examination survey†
Article first published online: 18 MAY 2011
Copyright © 2011 Wiley Periodicals, Inc.
Volume 72, Issue 2, pages 193–200, 1 February 2012
How to Cite
Lu, Z., Gao, Y., Tan, A., Yang, X., Zhang, H., Mo, L., Wu, C., Hu, Y. and Mo, Z. (2012), Increased high-sensitivity c-reactive protein predicts a high risk of lower urinary tract symptoms in chinese male: Results from the fangchenggang area male health and examination survey. Prostate, 72: 193–200. doi: 10.1002/pros.21421
- Issue published online: 22 DEC 2011
- Article first published online: 18 MAY 2011
- Manuscript Accepted: 14 APR 2011
- Manuscript Received: 23 JAN 2011
- National Natural Science Foundation of China. Grant Number: 30945204
- Provincial departments of Finance and Education, Guangxi Zhuang Autonomous Region, China. Grant Number: 2009GJCJ150
- benign prostatic hyperplasia;
Reports have shown that increased serum C-reactive protein (CRP) suggests a risk of lower urinary tract symptoms (LUTS) in the West population. However, few studies have investigated the role of CRP as regards LUTS in a Chinese male population.
Data were collected from 1,452 men who participated in the population-based Fangchenggang Area Male Health and Examination Survey (FAMHES), which was carried out in Guangxi, China, from September 2009 to December 2009. In the current study, serum CRP was measured with a high-sensitivity method (hsCRP) and LUTS was assessed by International Prostate Symptom Score (IPSS). Meanwhile, information about potential confounding variables (smoking, hypertension, diabetes, etc.) were included.
We observed that statistically significant distinction presented in the distribution of hsCRP levels and age between LUTS group and non-LUTS group (P < 0.001). Comparing with the lowest hsCRP tertile, men with the highest hsCRP tertile were 1.72 times more likely to have overall LUTS and 1.93 times more likely to have irritative symptoms. As for individual symptoms of LUTS, statistically significant correlations were noted between serum hsCRP levels and urgency (OR = 1.74, 95% CI = 1.09–2.78) and nocturia (OR = 1.64, 95% CI = 1.18–2.27), when comparing them from the 1st to 3rd hsCRP tertiles. After multivariate adjusted, the results changed slightly and were still significant.
In a Chinese male population, we firstly confirmed a positive correlation of serum hsCRP with LUTS. It can be inferred that inflammation may be involved in the processes of LUTS. Prostate 72:193–200, 2012. © 2011 Wiley Periodicals, Inc.