Original Article

BCAR1 expression improves prediction of biochemical reccurence after radical prostatectomy†

  1. Gaelle Fromont1,2,*,
  2. François Rozet3,
  3. Xavier Cathelineau3,
  4. Adil Ouzzane3,
  5. Laurent Doucet4,
  6. Georges Fournier5,
  7. Olivier Cussenot2,6

Article first published online: 12 JAN 2012

DOI: 10.1002/pros.22485

Issue

The Prostate

The Prostate

Volume 72, Issue 12, pages 1359–1365, 1 September 2012

Additional Information

How to Cite

Fromont, G., Rozet, F., Cathelineau, X., Ouzzane, A., Doucet, L., Fournier, G. and Cussenot, O. (2012), BCAR1 expression improves prediction of biochemical reccurence after radical prostatectomy. Prostate, 72: 1359–1365. doi: 10.1002/pros.22485

Author Information

  1. 1

    Department of Pathology, CHU/Universite de Poitiers, Poitiers, France

  2. 2

    Centre d'Etude et de Recherche sur les Pathologies Prostatiques, Paris, France

  3. 3

    Department of Urology, Institut Mutualiste Montsouris, Paris, France

  4. 4

    Department of Pathology, CHU/Universite de Brest, Brest, France

  5. 5

    Department of Urology, CHU/Universite de Brest, Brest, France

  6. 6

    ER2-UPMC, Hôpital Tenon, APHP, Paris, France

*Service d'Anatomie Pathologique, CHU Jean Bernard, Rue de la Miletrie, 86000 Poitiers, France.

  1. †

    Conflict of Interest: none to declare.

Publication History

  1. Issue published online: 23 JUL 2012
  2. Article first published online: 12 JAN 2012
  3. Manuscript Accepted: 13 DEC 2011
  4. Manuscript Received: 1 SEP 2011

Funded by

  • Programme hospitalier de recherche clinique (PHRC)

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Keywords:

  • BCAR1;
  • cell proliferation, estrogens;
  • prognosis;
  • prostatic neoplasms

Abstract

BACKGROUND

Because prostate cancer exhibits a great variability in clinical outcome, biomarkers that can be used in daily practice are needed to better stratify patients into prognostic groups. Since steroid hormones play a central role in the development and progression of prostate cancer, we aimed to analyze in a matched nested case–control study the value of molecules involved in steroid signaling, to predict recurrence after radical prostatectomy, independently from standard prognostic tools.

METHODS

Among 1,200 patients treated by radical prostatectomy with negative margins with at least 4 years follow-up, 121 prostate cancers with biochemical relapse were matched after pathological reassessment with 121 cancers with identical clinicopathological features but without relapse. Immunohistochemistry was performed on tissue microarrays, using antibodies directed against molecules involved in androgen and estrogen signaling, including hormone receptors, enzymes (such as the five alpha reductases 1,2 and 3, aromatase, alpha-keto reductase 1C3 and squalene epoxidase), the breast cancer antiestrogen resistance 1 (BCAR1), and the proliferation marker Ki67.

RESULTS

The median follow-up for patients without recurrence was 7 years. Both cell proliferation and BCAR1 expression were significantly associated with biochemical relapse, in univariate and multivariate analysis. In subgroup analysis, the sole predictive marker in patients with well-differentiated prostate cancer was BCAR1 (P = 0.004), whereas only proliferation (P = 0.001) was significantly associated with relapse in less-differentiated prostate cancer patients.

CONCLUSIONS

BCAR1 is an independent predictor of recurrence after radical prostatectomy for “low risk” prostate cancer. The use of this biomarker may enable more individualized treatment approaches. Prostate 72:1359–1365, 2012. © 2012 Wiley Periodicals, Inc.

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