Conflict of Interest: The authors report no conflict of interest.
Genetic Variants in 2q31 and 5p15 Are Associated With Aggressive Benign Prostatic Hyperplasia in a Chinese Population
Article first published online: 26 APR 2013
Copyright © 2013 Wiley Periodicals, Inc.
Volume 73, Issue 11, pages 1182–1190, August 2013
How to Cite
Qi, J., Tian, L., Chen, Z., Wang, L., Tao, S., Gu, X., Na, R., Jiao, Y., Kang, J., Zheng, S., Xu, J. and Sun, J. (2013), Genetic Variants in 2q31 and 5p15 Are Associated With Aggressive Benign Prostatic Hyperplasia in a Chinese Population. Prostate, 73: 1182–1190. doi: 10.1002/pros.22666
Jun Qi and Lu Tian contributed equally to this work.
- Issue published online: 21 JUN 2013
- Article first published online: 26 APR 2013
- Manuscript Accepted: 26 FEB 2013
- Manuscript Received: 17 DEC 2012
- National Science Foundation of China. Grant Number: 81070600
Benign prostatic hyperplasia (BPH) is a common disease prevalent in elderly men. However, the genetic determinants of BPH remain unclear. Because BPH and prostate cancer (PCa) share some common pathological characteristics, we investigated whether susceptibility loci for PCa contributed to BPH risk and BPH aggressiveness in Chinese men.
Fourteen SNPs associated with PCa risk in a Chinese population were genotyped in 426 BPH cases (184 aggressive and 242 non-aggressive BPH cases) and 1,008 controls. The association between the SNPs and BPH risk/aggressiveness was estimated using logistic regression analysis. In addition, effects of the 14 SNPs on BPH related clinical traits, including International Prostate Symptom Score (IPSS), prostate volume, total PSA, and free PSA were evaluated using linear regression analysis.
Two SNPs, rs12621278 in ITGA6 at 2q31 (OR = 0.82, P = 0.05) and rs339331 in RFX6 at 6q22 (OR = 1.22, P = 0.04) were significantly associated with BPH. In addition, rs12621278 (OR = 0.73, P = 0.05) and rs12653946, 13 kb upstream of IRX4 at 5p15 (OR = 1.40, 0.03), were significantly associated with aggressive BPH. Moreover, the risk allele of rs12621278 (G) and rs12653946 (T) for aggressive BPH were significantly associated with elevated IPSS after treatment (P = 0.01).
This is the first systematic investigation on the contributions of PCa susceptibility loci to risk and aggressiveness of BPH. Our findings advance our understanding of the genetic basis of BPH, especially aggressive BPH. In addition, our results provide new insights into the genetic determinants shared between BPH and PCa. Prostate 73: 1182–1190, 2013. © 2013 Wiley Periodicals, Inc.