First authorship shared by Dr. Bensen and Dr. Xu.
Admixture mapping of prostate cancer in African Americans participating in the North Carolina-Louisiana Prostate Cancer Project (PCaP)
Version of Record online: 4 SEP 2013
© 2013 Wiley Periodicals, Inc.
Volume 74, Issue 1, pages 1–9, January 2014
How to Cite
Bensen, J. T., Xu, Z., McKeigue, P. M., Smith, G. J., Fontham, E. T.H., Mohler, J. L. and Taylor, J. A. (2014), Admixture mapping of prostate cancer in African Americans participating in the North Carolina-Louisiana Prostate Cancer Project (PCaP). Prostate, 74: 1–9. doi: 10.1002/pros.22722
No potential conflicts of interest were disclosed.
- Issue online: 6 DEC 2013
- Version of Record online: 4 SEP 2013
- Manuscript Accepted: 22 JUL 2013
- Manuscript Received: 28 MAY 2013
- National Institute of Environmental Health Sciences, NIH. Grant Number: Z01 ES049033
- ancestry informative markers;
- prostate cancer;
- African American;
- mapping by admixture linkage disequilibrium;
Few genetic risk factors have been uncovered that contribute specifically to the racial disparity in prostate cancer (CaP) observed in African Americans (AA). With the advent of ancestry informative marker (AIM) single nucleotide polymorphism (SNP) panels and powerful genetic strategies such as mapping by admixture linkage disequilibrium (MALD) it is possible to discover genes that underlie ethnic variation in disease risk.
One thousand one hundred thirty AA CaP cases enrolled in the North Carolina-Louisiana Prostate Cancer Project (PCaP) were genotyped using a 1,509 AIM SNP panel. MALD was performed using ADMIXMAP to test for linkage between CaP risk and ancestry estimates at each AIM SNP.
The largest increase of African ancestry was observed at marker rs12543473 (P = 0.0011), located on chromosome 8q24.21, and the greatest excess of European ancestry was observed at marker rs10768140 (P = 0.0004) at chromosome 11p13.
The study confirmed the 8q24 risk loci and identified a novel genomic region on 11p13 that is associated with CaP risk. These findings should be replicated in larger AA populations and combined with fine mapping data to further refine the novel 11p13 CaP risk loci. Prostate 74:1–9, 2014. © 2013 Wiley Periodicals, Inc.