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Admixture mapping of prostate cancer in African Americans participating in the North Carolina-Louisiana Prostate Cancer Project (PCaP)

Authors

  • Jeannette T. Bensen,

    1. Department of Epidemiology, Division of Urology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    2. Lineberger Comprehensive Cancer Center, Division of Urology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
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    • First authorship shared by Dr. Bensen and Dr. Xu.
  • Zongli Xu,

    1. Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
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    • First authorship shared by Dr. Bensen and Dr. Xu.
  • Paul M. McKeigue,

    1. Center for Population Health Sciences, University of Edinburgh Medical School, Tevoit Place, Edinburgh, United Kingdom
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  • Gary J. Smith,

    1. Department of Urology, Roswell Park Cancer Institute, Buffalo, New York
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  • Elizabeth T.H. Fontham,

    1. School of Public Health, Louisiana State University Health Science Center, New Orleans, Louisiana
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  • James L. Mohler,

    1. Lineberger Comprehensive Cancer Center, Division of Urology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    2. Department of Urology, Roswell Park Cancer Institute, Buffalo, New York
    3. Department of Urology, University of Buffalo School of Medicine and Biotechnology, Buffalo, New York
    4. Department of Surgery, Division of Urology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
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  • Jack A. Taylor

    Corresponding author
    1. Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
    2. Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
    • Correspondence to: Jack A. Taylor, National Institute of Environmental Health Sciences, MD A3-05, 111 TW Alexander Dr., PO Box 12233, Research Triangle Park, NC 27709. E-mail: taylor@niehs.nih.gov

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  • No potential conflicts of interest were disclosed.

Abstract

BACKGROUND

Few genetic risk factors have been uncovered that contribute specifically to the racial disparity in prostate cancer (CaP) observed in African Americans (AA). With the advent of ancestry informative marker (AIM) single nucleotide polymorphism (SNP) panels and powerful genetic strategies such as mapping by admixture linkage disequilibrium (MALD) it is possible to discover genes that underlie ethnic variation in disease risk.

METHODS

One thousand one hundred thirty AA CaP cases enrolled in the North Carolina-Louisiana Prostate Cancer Project (PCaP) were genotyped using a 1,509 AIM SNP panel. MALD was performed using ADMIXMAP to test for linkage between CaP risk and ancestry estimates at each AIM SNP.

RESULTS

The largest increase of African ancestry was observed at marker rs12543473 (P = 0.0011), located on chromosome 8q24.21, and the greatest excess of European ancestry was observed at marker rs10768140 (P = 0.0004) at chromosome 11p13.

CONCLUSIONS

The study confirmed the 8q24 risk loci and identified a novel genomic region on 11p13 that is associated with CaP risk. These findings should be replicated in larger AA populations and combined with fine mapping data to further refine the novel 11p13 CaP risk loci. Prostate 74:1–9, 2014. © 2013 Wiley Periodicals, Inc.

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