Some questions raised by histologic study of RTOG protocols 75–06 and 77–06 as illustrated by selected samples


  • Roger Terry MD

    Corresponding author
    1. Los Angeles County-University of Southern California Medical Center, Los Angeles
    • 2841 Shakespeare Dr., San Marino, CA 91108
    Search for more papers by this author


Histologic study of about 700 biopsy specimens from patients with prostate cancers collected by the Radiation Therapy Oncology Group (RTOG) reemphasized the difficulty in accurately predicting biologic behavior of the carcinoma in individual cases. Some well-differentiated carcinomas metastasized to regional lymph nodes. Histologic proof of lymph node metastases may be difficult to detect. Some duct carcinomas do not readily fit a Gleason pattern. A variety of histologic grades may be seen either in a single sample or after the passage of time in the same case. Some prostatic epithelial proliferations may closely simulate carcinomas by routine light microscopy, but are biologically benign. Some of these prostate lesions have histologic similarities to breast lesions.