Effect of molybdate on androgen receptor levels in canine prostate

Authors

  • Dr. Wesley Y. Naritoku,

    Corresponding author
    1. Department of Pathology, and the University of Southern California Comprehensive Cancer Center, University of Southern California School of Medicine, Los Angeles
    • Department of Pathology, USC School of Medicine, 2025 Zonal Avenue, Los Angeles, CA 90033
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  • Edwin B. Howard,

    1. Department of Pathology, and the University of Southern California Comprehensive Cancer Center, University of Southern California School of Medicine, Los Angeles
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  • James O. Britt,

    1. Department of Pathology, and the University of Southern California Comprehensive Cancer Center, University of Southern California School of Medicine, Los Angeles
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  • Francis S. Markland Jr

    1. Department of Biochemistry, and the University of Southern California Comprehensive Cancer Center, University of Southern California School of Medicine, Los Angeles
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Abstract

A comparative study on the stabilizing effect of sodium molybdate on androgen receptors was performed using canine prostates. Prostates from intact male dogs of mixed breeds were run in parallel sucrose density gradient analyses, using buffer systems with or without molybdate. Prostates that were homogenized in a molybdate buffer showed a significant increase in androgen receptor content relative to those in a molybdate-free system.

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