Family history and the risk of prostate cancer
Article first published online: 20 JUL 2006
Copyright © 1990 Wiley-Liss, Inc., A Wiley Company
Volume 17, Issue 4, pages 337–347, 1990
How to Cite
Steinberg, G. D., Carter, B. S., Beaty, T. H., Childs, B. and Walsh, P. C. (1990), Family history and the risk of prostate cancer. Prostate, 17: 337–347. doi: 10.1002/pros.2990170409
- Issue published online: 20 JUL 2006
- Article first published online: 20 JUL 2006
- Manuscript Accepted: 22 OCT 1990
- Manuscript Received: 6 AUG 1990
- NIH. Grant Number: CA9132
- familial aggregation;
- risk factors;
- genetic epidemiology
A case-control study was performed to estimate the relative risk of developing prostate cancer for men with a positive family history. Extensive cancer pedigrees were obtained on 691 men with prostate cancer and 640 spouse controls.
Fifteen percent of the cases but only 8% of the controls had a father or brother affected with prostate cancer (P < .001). Men with a father or brother affected were twice as likely to develop prostate cancer as men with no relatives affected. In addition, there was a trend of increasing risk with increasing number of affected family members such that men with two or three first degree relatives affected had a five and 11–fold increased risk of developing prostate cancer.
Recognizing that 9–10% of U.S. men will develop prostate cancer in their lifetime, men with a family history of prostate cancer should be advised of their significantly increased prostate cancer risk and should undergo appropriate screening measures for this disease.