The proliferative function of basal cells in the normal and hyperplastic human prostate
Article first published online: 20 JUL 2006
Copyright © 1994 Wiley-Liss, Inc., A Wiley Company
Volume 24, Issue 3, pages 114–118, March 1994
How to Cite
Bonkhoff, H., Stein, U. and Remberger, K. (1994), The proliferative function of basal cells in the normal and hyperplastic human prostate. Prostate, 24: 114–118. doi: 10.1002/pros.2990240303
- Issue published online: 20 JUL 2006
- Article first published online: 20 JUL 2006
- Manuscript Accepted: 18 JUN 1993
- Manuscript Received: 11 NOV 1992
- MIB 1;
- immunohistochemical double stainings
To obtain more insight into the proliferative function of basal and secretory cell types in human prostate, we studied the immunoprofile of three well-characterized proliferation-associated antigens (Ki-67, PCNA, MIB 1) in normal and hyperplastic prostate tissue. Distinction between labeled basal and secretory cell types was made by simultaneous demonstration of the proliferation-associated antigens and basal cell-specific cytokeratins in identical sections. In normal and hyperplastic acini, approximately 70% of labeled cells were of the basal cell phenotype. These data clearly suggest that the proliferative compartment of the normal and hyperplastic epithelium is located in the basal cell layer. Compared to normal and hyperplastic conditions, severe proliferative abnormalities were detected in high-grade prostate intraepithelial neoplasias (PIN), as documented by the extension of the proliferative compartment up to the luminal border. Conversely, approximately 70% of proliferating cells detected in atypical hyperplasias that progressed in invasive carcinomas were localized in the remaining basal cell layer.
These findings may indicate the proliferative role of basal cells in the epithelial renewal, and the development of hyperplastic and neoplastic disorders in the human prostate. © 1994 Wiley-Liss, Inc.