Research Article

CAPRI: A Critical Assessment of PRedicted Interactions

  1. Joël Janin1,*,
  2. Kim Henrick2,
  3. John Moult3,
  4. Lynn Ten Eyck4,
  5. Michael J. E. Sternberg5,
  6. Sandor Vajda6,
  7. Ilya Vakser7,
  8. Shoshana J. Wodak8

Article first published online: 13 MAY 2003

DOI: 10.1002/prot.10381

Issue

Proteins: Structure, Function, and Bioinformatics

Proteins: Structure, Function, and Bioinformatics

Special Issue: CAPRI—Critical Assessment of PRedicted Interactions

Volume 52, Issue 1, pages 2–9, 1 July 2003

Additional Information

How to Cite

Janin, J., Henrick, K., Moult, J., Eyck, L. T., Sternberg, M. J. E., Vajda, S., Vakser, I. and Wodak, S. J. (2003), CAPRI: A Critical Assessment of PRedicted Interactions. Proteins: Structure, Function, and Bioinformatics, 52: 2–9. doi: 10.1002/prot.10381

Author Information

  1. 1

    Laboratoire d'Enzymologie et Biochimie Structurales, CNRS, Gif-sur-Yvette, France

  2. 2

    European Bioinformatics Institute (EBI-EMBL), Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

  3. 3

    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland

  4. 4

    San Diego Supercomputer Center, UCSD 0505, La Jolla, California

  5. 5

    Structural Bioinformatics, Biochemistry Building, Department of Biological Sciences, Imperial College, London, United Kingdom

  6. 6

    Biomedical Engineering, Boston University, Boston, Massachusetts

  7. 7

    Bioinformatics Laboratory, Department of Applied Mathematics and Statistics, SUNY at Stony Brook, Stony Brook, New York

  8. 8

    Service de Conformation de Macromolécules Biologiques et Bioinformatique, Campus Plaine-BC6, Université Libre de Bruxelles, Brusssels, Belgium

*Laboratoire d'Enzymologie et Biochimie Structurales-CNRS, 91198 Gif-sur-Yvette, France

Publication History

  1. Issue published online: 13 MAY 2003
  2. Article first published online: 13 MAY 2003
  3. Manuscript Accepted: 19 DEC 2002
  4. Manuscript Received: 13 DEC 2002

Funded by

  • Centre National de la Recherche Scientifique (CNRS, France)
  • Fonds National de la Recherche Scientifique (FNRS, Belgium)
  • Action Informatique Mathématiques Physique pour la Génomique (IMPG, Ministry of Education, France)
  • The International Society for Computational Biology (ISCB)
  • Astra-Zeneca
  • Glaxo-Smith-Kline
  • Organon International
  • Hewlett-Packard

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Keywords:

  • protein–protein interaction;
  • docking;
  • blind prediction

Abstract

CAPRI is a communitywide experiment to assess the capacity of protein-docking methods to predict protein–protein interactions. Nineteen groups participated in rounds 1 and 2 of CAPRI and submitted blind structure predictions for seven protein–protein complexes based on the known structure of the component proteins. The predictions were compared to the unpublished X-ray structures of the complexes. We describe here the motivations for launching CAPRI, the rules that we applied to select targets and run the experiment, and some conclusions that can already be drawn. The results stress the need for new scoring functions and for methods handling the conformation changes that were observed in some of the target systems. CAPRI has already been a powerful drive for the community of computational biologists who development docking algorithms. We hope that this issue of Proteins will also be of interest to the community of structural biologists, which we call upon to provide new targets for future rounds of CAPRI, and to all molecular biologists who view protein–protein recognition as an essential process. Proteins 2003;52:2–9. © 2003 Wiley-Liss, Inc.

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