Relationship between protein structures and disulfide-bonding patterns

Authors

  • Chao-Chun Chuang,

    1. Department of Life Sciences, Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsin Chu, Taiwan
    2. Department of Biological Science and Technology, Institute of Bioinformatics, National Chiao Tung University, Hsin Chu, Taiwan
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  • Chun-Yin Chen,

    1. Department of Biological Science and Technology, Institute of Bioinformatics, National Chiao Tung University, Hsin Chu, Taiwan
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  • Jinn-Moon Yang,

    1. Department of Biological Science and Technology, Institute of Bioinformatics, National Chiao Tung University, Hsin Chu, Taiwan
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  • Ping-Chiang Lyu,

    Corresponding author
    1. Department of Life Sciences, Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsin Chu, Taiwan
    • Department of Life Sciences, Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsin Chu, Taiwan
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  • Jenn-Kang Hwang

    Corresponding author
    1. Department of Biological Science and Technology, Institute of Bioinformatics, National Chiao Tung University, Hsin Chu, Taiwan
    • Department of Biological Science and Technology, Institute of Bioinformatics, National Chiao Tung University, Hsin Chu, Tawiwan
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Abstract

We found that that disulfide-bonding patterns can be used to discriminate structure similarity. Our method, based on the hierarchical clustering scheme, is applicable to proteins with two or more disulfide bonds and is able to detect the structural similarities of proteins of low sequence identities (<25%). Our results show the surprisingly close relationship between disulfide-bonding patterns and proteins structures. Our findings should be useful in protein structure modeling. Proteins 2003. © 2003 Wiley-Liss, Inc.

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