Short Communication

Relationship between protein structures and disulfide-bonding patterns

  1. Chao-Chun Chuang1,2,
  2. Chun-Yin Chen2,
  3. Jinn-Moon Yang2,
  4. Ping-Chiang Lyu1,*,
  5. Jenn-Kang Hwang2,*

Article first published online: 5 AUG 2003

DOI: 10.1002/prot.10492

Issue

Proteins: Structure, Function, and Bioinformatics

Proteins: Structure, Function, and Bioinformatics

Volume 53, Issue 1, pages 1–5, October 2003

Additional Information

How to Cite

Chuang, C.-C., Chen, C.-Y., Yang, J.-M., Lyu, P.-C. and Hwang, J.-K. (2003), Relationship between protein structures and disulfide-bonding patterns. Proteins: Structure, Function, and Bioinformatics, 53: 1–5. doi: 10.1002/prot.10492

Author Information

  1. 1

    Department of Life Sciences, Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsin Chu, Taiwan

  2. 2

    Department of Biological Science and Technology, Institute of Bioinformatics, National Chiao Tung University, Hsin Chu, Taiwan

*Department of Life Sciences, Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsin Chu, Taiwan

Publication History

  1. Issue published online: 21 AUG 2003
  2. Article first published online: 5 AUG 2003
  3. Manuscript Accepted: 28 APR 2003
  4. Manuscript Received: 25 DEC 2002

Funded by

  • National Science Council in Taiwan
  • Republic of China

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Keywords:

  • disulfide-bonding patterns;
  • the hierarchical clustering method;
  • structure classification

Abstract

We found that that disulfide-bonding patterns can be used to discriminate structure similarity. Our method, based on the hierarchical clustering scheme, is applicable to proteins with two or more disulfide bonds and is able to detect the structural similarities of proteins of low sequence identities (<25%). Our results show the surprisingly close relationship between disulfide-bonding patterns and proteins structures. Our findings should be useful in protein structure modeling. Proteins 2003. © 2003 Wiley-Liss, Inc.

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