Comp. Modeling: Assessment

Assessment of homology-based predictions in CASP5

  1. Anna Tramontano1,*,
  2. Veronica Morea2

Article first published online: 15 OCT 2003

DOI: 10.1002/prot.10543

Issue

Proteins: Structure, Function, and Bioinformatics

Proteins: Structure, Function, and Bioinformatics

Supplement: Fifth Meeting on the Critical Assessment of Techniques for Protein Structure Prediction

Volume 53, Issue Supplement 6, pages 352–368, 2003

Additional Information

How to Cite

Tramontano, A. and Morea, V. (2003), Assessment of homology-based predictions in CASP5. Proteins, 53: 352–368. doi: 10.1002/prot.10543

Author Information

  1. 1

    Department of Biochemical Sciences, “A. Rossi Fanelli,” University of Rome “La Sapienza,” Rome, Italy

  2. 2

    CNR Institute of Molecular Biology and Pathology, University of Rome “La Sapienza,” Rome, Italy

*Department of Biochemical Sciences “A. Rossi Fanelli,” University of Rome “La Sapienza,” P.le Aldo Moro, 5-00185 Rome, Italy

Publication History

  1. Issue published online: 15 OCT 2003
  2. Article first published online: 15 OCT 2003
  3. Manuscript Accepted: 23 JUN 2003
  4. Manuscript Received: 4 MAR 2003

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Abstract

This report describes the assessment of the homology-based predictions submitted to the fifth edition of the Critical Assessment of Methods for Protein Structure Prediction (CASP5) experiment. We assessed the ability of the methods to predict the overall fold, the portions of the structure that differ substantially between the target protein and its closest structural homologue and the conformation of the side-chains. We also compared the results with those obtained in previous editions of the experiment and derived some general conclusions about the state of the art of comparative modeling methods and their usefulness for experimentalists. Proteins 2003;53:352–368. © 2003 Wiley-Liss, Inc.

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