Assessment of homology-based predictions in CASP5

Authors

  • Anna Tramontano,

    Corresponding author
    1. Department of Biochemical Sciences, “A. Rossi Fanelli,” University of Rome “La Sapienza,” Rome, Italy
    • Department of Biochemical Sciences “A. Rossi Fanelli,” University of Rome “La Sapienza,” P.le Aldo Moro, 5-00185 Rome, Italy
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  • Veronica Morea

    1. CNR Institute of Molecular Biology and Pathology, University of Rome “La Sapienza,” Rome, Italy
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Abstract

This report describes the assessment of the homology-based predictions submitted to the fifth edition of the Critical Assessment of Methods for Protein Structure Prediction (CASP5) experiment. We assessed the ability of the methods to predict the overall fold, the portions of the structure that differ substantially between the target protein and its closest structural homologue and the conformation of the side-chains. We also compared the results with those obtained in previous editions of the experiment and derived some general conclusions about the state of the art of comparative modeling methods and their usefulness for experimentalists. Proteins 2003;53:352–368. © 2003 Wiley-Liss, Inc.

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