1097-0134/asset/PROT_centre.gif?v=1&s=77b56b1f2cdaba74cb3bb149bd9b029cd8803cdb)
Fold Recognition: Prediction Reports
Application of 3D-Jury, GRDB, and Verify3D in fold recognition
Article first published online: 15 OCT 2003
DOI: 10.1002/prot.10547
Copyright © 2003 Wiley-Liss, Inc.
Issue
1097-0134/asset/cover.gif?v=1&s=d817e79b67ba6cacf8bdcce1a819c04de300a7e3 "Proteins: Structure, Function, and Bioinformatics")
Proteins: Structure, Function, and Bioinformatics
Supplement: Fifth Meeting on the Critical Assessment of Techniques for Protein Structure Prediction
Volume 53, Issue Supplement 6, pages 418–423, 2003
Additional Information
How to Cite
Grotthuss, M. v., Pas, J., Wyrwicz, L., Ginalski, K. and Rychlewski, L. (2003), Application of 3D-Jury, GRDB, and Verify3D in fold recognition. Proteins, 53: 418–423. doi: 10.1002/prot.10547
Publication History
- Issue published online: 15 OCT 2003
- Article first published online: 15 OCT 2003
- Manuscript Accepted: 17 MAR 2003
- Manuscript Received: 17 FEB 2003
Funded by
- CASP
- Abstract
- Article
- References
- Cited By
Keywords:
- CASP;
- protein structure prediction;
- 3D-Jury;
- Meta Server;
- Verify3D;
- GRDB
Abstract
In CASP5, the BioInfo.PL group has used the structure prediction Meta Server and the associated newly developed flexible meta-predictor, called 3D-Jury, as the main structure prediction tools. The most important feature of the meta-predictor is a high (86%) correlation between the reported confidence score and the quality of the selected model. The Gene Relational Database (GRDB) was used to confirm the fold recognition results by selecting distant homologues and subsequent structure prediction with the Meta Server. A fragment-splicing procedure was performed as a final processing step with large fragments extracted from selected models using model quality control provided by Verify3D. The comparison of submitted models with the native structure conducted after the CASP meeting showed that the GRDB-supported structure prediction led to a satisfactory template fold selection, whereas the fragment-splicing procedure must be improved in the future. Proteins 2003;53:418–423. © 2003 Wiley-Liss, Inc.