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Ab Initio: Prediction Report
Rosetta in CASP4: Progress in ab initio protein structure prediction
Article first published online: 28 JAN 2002
DOI: 10.1002/prot.1170
Copyright © 2002 Wiley-Liss, Inc.
Issue
1097-0134/asset/cover.gif?v=1&s=d817e79b67ba6cacf8bdcce1a819c04de300a7e3 "Proteins: Structure, Function, and Bioinformatics")
Proteins: Structure, Function, and Bioinformatics
Supplement: Fourth Meeting on the Critical Assessment of Techniques for Protein Structure Prediction
Volume 45, Issue Supplement 5, pages 119–126, 2001
Additional Information
How to Cite
Bonneau, R., Tsai, J., Ruczinski, I., Chivian, D., Rohl, C., Strauss, C. E. M. and Baker, D. (2001), Rosetta in CASP4: Progress in ab initio protein structure prediction. Proteins: Structure, Function, and Bioinformatics, 45: 119–126. doi: 10.1002/prot.1170
Publication History
- Issue published online: 28 JAN 2002
- Article first published online: 28 JAN 2002
- Manuscript Accepted: 2 JUL 2001
- Manuscript Received: 10 APR 2001
- Abstract
- Article
- References
- Cited By
Keywords:
- contact order;
- Rosetta;
- CASP;
- structure prediction;
- clustering;
- fold complexity;
- topology
Abstract
Rosetta ab initio protein structure predictions in CASP4 were considerably more consistent and more accurate than previous ab initio structure predictions. Large segments were correctly predicted (>50 residues superimposed within an RMSD of 6.5 Å) for 16 of the 21 domains under 300 residues for which models were submitted. Models with the global fold largely correct were produced for several targets with new folds, and for several difficult fold recognition targets, the Rosetta models were more accurate than those produced with traditional fold recognition models. These promising results suggest that Rosetta may soon be able to contribute to the interpretation of genome sequence information. Proteins 2001;Suppl 5:119–126. © 2002 Wiley-Liss, Inc.