Predicting novel protein folds by using FRAGFOLD


  • David T. Jones

    1. Department of Biological Sciences, Brunel University, Uxbridge, Middlesex, United Kingdom
    Current affiliation:
    1. Bioinformatics Unit, Department of Computer Science, University College London, Gower Street, London WC1E 6BT United Kingdom
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The results of applying a fragment-based protein tertiary structure prediction method to the prediction of 8 CASP4 targets are described. The method is based on the assembly of supersecondary structural fragments taken from highly resolved protein structures using a simulated annealing algorithm. Despite the significant degree of success in this case, there is clearly much more developmental work required before predictions with the accuracy of a good homology model, or even a good fold recognition model, can be made with use of this kind of approach. Proteins 2001;Suppl 5:127–132. © 2002 Wiley-Liss, Inc.