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Review Article
Principles of nanostructure design with protein building blocks
Article first published online: 3 APR 2007
DOI: 10.1002/prot.21413
Copyright © 2007 Wiley-Liss, Inc.
1097-0134/asset/cover.gif?v=1&s=d817e79b67ba6cacf8bdcce1a819c04de300a7e3 "Proteins: Structure, Function, and Bioinformatics")
Additional Information
How to Cite
Tsai, C.-J., Zheng, J., Zanuy, D., Haspel, N., Wolfson, H., Alemán, C. and Nussinov, R. (2007), Principles of nanostructure design with protein building blocks. Proteins: Structure, Function, and Bioinformatics, 68: 1–12. doi: 10.1002/prot.21413
Publication History
- Issue published online: 21 MAY 2007
- Article first published online: 3 APR 2007
- Manuscript Accepted: 24 DEC 2006
- Manuscript Revised: 5 DEC 2006
- Manuscript Received: 5 SEP 2006
Funded by
- National Institute of Health. Grant Number: NO1-CO-12400
- National Cancer Institute
- Center for Cancer Research
- Intramural Research Program of the NIH
- Abstract
- Article
- References
- Cited By
Keywords:
- nanostructure design;
- protein building blocks;
- self-assembly;
- protein folding;
- repeat proteins
Abstract
Currently there is increasing interest in nanostructures and their design. Nanostructure design involves the ability to predictably manipulate the properties of the self-assembly of autonomous units. Autonomous units have preferred conformational states. The units can be synthetic material science-based or derived from functional biological macromolecules. Autonomous biological building blocks with available structures provide an extremely rich and useful resource for design. For proteins, the structural databases contain large libraries of protein molecules and their building blocks with a range of shapes, surfaces, and chemical properties. The introduction of engineered synthetic residues or short peptides into these can expand the available chemical space and enhance the desired properties. Here we focus on the principles of nanostructure design with protein building blocks. Proteins 2007. © 2007 Wiley-Liss, Inc.