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Crystal structure of MtnX phosphatase from Bacillus subtilis at 2.0 Å resolution provides a structural basis for bipartite phosphomonoester hydrolysis of 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate

Authors

  • Qingping Xu,

    1. Joint Center for Structural Genomics (JCSG)
    2. Stanford Synchrotron Radiation Laboratory, Stanford University, Menlo Park, California
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    • Qingping Xu and Kumar Singh Saikatendu contributed equally to this work.

  • Kumar Singh Saikatendu,

    1. The Scripps Research Institute, La Jolla, California
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    • Qingping Xu and Kumar Singh Saikatendu contributed equally to this work.

  • S. Sri Krishna,

    1. Joint Center for Structural Genomics (JCSG)
    2. Burnham Institute for Medical Research, La Jolla, California
    3. Center for Research in Biological Systems, University of California, San Diego, La Jolla, California
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  • Daniel McMullan,

    1. Joint Center for Structural Genomics (JCSG)
    2. Genomics Institute of the Novartis Research Foundation, San Diego, California
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  • Polat Abdubek,

    1. Joint Center for Structural Genomics (JCSG)
    2. Genomics Institute of the Novartis Research Foundation, San Diego, California
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  • Sanjay Agarwalla,

    1. Joint Center for Structural Genomics (JCSG)
    2. Genomics Institute of the Novartis Research Foundation, San Diego, California
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  • Eileen Ambing,

    1. Joint Center for Structural Genomics (JCSG)
    2. Genomics Institute of the Novartis Research Foundation, San Diego, California
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  • Tamara Astakhova,

    1. Joint Center for Structural Genomics (JCSG)
    2. Center for Research in Biological Systems, University of California, San Diego, La Jolla, California
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  • Herbert L. Axelrod,

    1. Joint Center for Structural Genomics (JCSG)
    2. Stanford Synchrotron Radiation Laboratory, Stanford University, Menlo Park, California
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  • Dennis Carlton,

    1. Joint Center for Structural Genomics (JCSG)
    2. The Scripps Research Institute, La Jolla, California
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  • Hsiu-Ju Chiu,

    1. Joint Center for Structural Genomics (JCSG)
    2. Stanford Synchrotron Radiation Laboratory, Stanford University, Menlo Park, California
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  • Thomas Clayton,

    1. Joint Center for Structural Genomics (JCSG)
    2. The Scripps Research Institute, La Jolla, California
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  • Michael DiDonato,

    1. Joint Center for Structural Genomics (JCSG)
    2. Genomics Institute of the Novartis Research Foundation, San Diego, California
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  • Lian Duan,

    1. Joint Center for Structural Genomics (JCSG)
    2. Center for Research in Biological Systems, University of California, San Diego, La Jolla, California
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  • Marc-André Elsliger,

    1. Joint Center for Structural Genomics (JCSG)
    2. The Scripps Research Institute, La Jolla, California
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  • Julie Feuerhelm,

    1. Joint Center for Structural Genomics (JCSG)
    2. Genomics Institute of the Novartis Research Foundation, San Diego, California
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  • Slawomir K. Grzechnik,

    1. Joint Center for Structural Genomics (JCSG)
    2. Center for Research in Biological Systems, University of California, San Diego, La Jolla, California
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  • Joanna Hale,

    1. Joint Center for Structural Genomics (JCSG)
    2. Genomics Institute of the Novartis Research Foundation, San Diego, California
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  • Eric Hampton,

    1. Joint Center for Structural Genomics (JCSG)
    2. Genomics Institute of the Novartis Research Foundation, San Diego, California
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  • Gye Won Han,

    1. Joint Center for Structural Genomics (JCSG)
    2. The Scripps Research Institute, La Jolla, California
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  • Justin Haugen,

    1. Joint Center for Structural Genomics (JCSG)
    2. Genomics Institute of the Novartis Research Foundation, San Diego, California
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  • Lukasz Jaroszewski,

    1. Joint Center for Structural Genomics (JCSG)
    2. Burnham Institute for Medical Research, La Jolla, California
    3. Center for Research in Biological Systems, University of California, San Diego, La Jolla, California
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  • Kevin K. Jin,

    1. Joint Center for Structural Genomics (JCSG)
    2. Stanford Synchrotron Radiation Laboratory, Stanford University, Menlo Park, California
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  • Heath E. Klock,

    1. Joint Center for Structural Genomics (JCSG)
    2. Genomics Institute of the Novartis Research Foundation, San Diego, California
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  • Mark W. Knuth,

    1. Joint Center for Structural Genomics (JCSG)
    2. Genomics Institute of the Novartis Research Foundation, San Diego, California
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  • Eric Koesema,

    1. Joint Center for Structural Genomics (JCSG)
    2. Genomics Institute of the Novartis Research Foundation, San Diego, California
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  • Mitchell D. Miller,

    1. Joint Center for Structural Genomics (JCSG)
    2. Stanford Synchrotron Radiation Laboratory, Stanford University, Menlo Park, California
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  • Andrew T. Morse,

    1. Joint Center for Structural Genomics (JCSG)
    2. Center for Research in Biological Systems, University of California, San Diego, La Jolla, California
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  • Edward Nigoghossian,

    1. Joint Center for Structural Genomics (JCSG)
    2. Genomics Institute of the Novartis Research Foundation, San Diego, California
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  • Linda Okach,

    1. Joint Center for Structural Genomics (JCSG)
    2. Genomics Institute of the Novartis Research Foundation, San Diego, California
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  • Silvya Oommachen,

    1. Joint Center for Structural Genomics (JCSG)
    2. Stanford Synchrotron Radiation Laboratory, Stanford University, Menlo Park, California
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  • Jessica Paulsen,

    1. Joint Center for Structural Genomics (JCSG)
    2. Genomics Institute of the Novartis Research Foundation, San Diego, California
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  • Ron Reyes,

    1. Joint Center for Structural Genomics (JCSG)
    2. Stanford Synchrotron Radiation Laboratory, Stanford University, Menlo Park, California
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  • Christopher L. Rife,

    1. Joint Center for Structural Genomics (JCSG)
    2. Stanford Synchrotron Radiation Laboratory, Stanford University, Menlo Park, California
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  • Robert Schwarzenbacher,

    1. Joint Center for Structural Genomics (JCSG)
    2. Center for Research in Biological Systems, University of California, San Diego, La Jolla, California
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  • Henry van den Bedem,

    1. Joint Center for Structural Genomics (JCSG)
    2. Stanford Synchrotron Radiation Laboratory, Stanford University, Menlo Park, California
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  • Aprilfawn White,

    1. Joint Center for Structural Genomics (JCSG)
    2. Genomics Institute of the Novartis Research Foundation, San Diego, California
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  • Guenter Wolf,

    1. Joint Center for Structural Genomics (JCSG)
    2. Stanford Synchrotron Radiation Laboratory, Stanford University, Menlo Park, California
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  • Keith O. Hodgson,

    1. Joint Center for Structural Genomics (JCSG)
    2. Stanford Synchrotron Radiation Laboratory, Stanford University, Menlo Park, California
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  • John Wooley,

    1. Joint Center for Structural Genomics (JCSG)
    2. Center for Research in Biological Systems, University of California, San Diego, La Jolla, California
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  • Ashley M. Deacon,

    1. Joint Center for Structural Genomics (JCSG)
    2. Stanford Synchrotron Radiation Laboratory, Stanford University, Menlo Park, California
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  • Adam Godzik,

    1. Joint Center for Structural Genomics (JCSG)
    2. Burnham Institute for Medical Research, La Jolla, California
    3. Center for Research in Biological Systems, University of California, San Diego, La Jolla, California
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  • Scott A. Lesley,

    1. Joint Center for Structural Genomics (JCSG)
    2. The Scripps Research Institute, La Jolla, California
    3. Genomics Institute of the Novartis Research Foundation, San Diego, California
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  • Ian A. Wilson

    Corresponding author
    1. Joint Center for Structural Genomics (JCSG)
    2. The Scripps Research Institute, La Jolla, California
    • JCSG, The Scripps Research Institute, BCC206, 10550 North Torrey Pines Road, La Jolla, CA 92037
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Abstract

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