The author states no conflict of interest.
The targets of CAPRI Rounds 13–19
Article first published online: 20 MAY 2010
Copyright © 2010 Wiley-Liss, Inc.
Proteins: Structure, Function, and Bioinformatics
Special Issue: Fourth Meeting on the Critical Assessment of PRedicted Interactions
Volume 78, Issue 15, pages 3067–3072, 15 November 2010
How to Cite
Janin, J. (2010), The targets of CAPRI Rounds 13–19. Proteins, 78: 3067–3072. doi: 10.1002/prot.22774
- Issue published online: 20 MAY 2010
- Article first published online: 20 MAY 2010
- Manuscript Accepted: 11 MAY 2010
- Manuscript Revised: 28 APR 2010
- Manuscript Received: 16 FEB 2010
- 3D-Repertoire and SPINE2-Complex programs of the European Union
- ARCUS-Inde program of the French Ministry of Foreign Affairs
- Région Ile-de-France
- protein–protein interaction;
- protein docking;
- blind prediction;
- community-wide experiment
Seven rounds of CAPRI predictions with a total of 14 targets were held in the period June 2007–November 2009. In addition to protease/inhibitor complexes and complexes with G-proteins, some of the targets displayed novel features presenting new challenges to the predictors: a complex with RNA, a leucine zipper to be built abinitio, and a human-designed protein. Nine targets were unbound or required model building; the other five had a bound component. Thirteen were assessed, and the results show that the predictor and scorer groups submitted two- or three-star (medium or high quality) models for eight of them, one-star (acceptable) models for three but failed on the unbound RNA complex and another unbound target. Proteins 2010. © 2010 Wiley-Liss, Inc.