The authors state no conflict of interest.
Assessment of Other Categories of Predictions
Evaluation of residue–residue contact predictions in CASP9†
Article first published online: 17 SEP 2011
Copyright © 2011 Wiley-Liss, Inc.
Proteins: Structure, Function, and Bioinformatics
Volume 79, Issue Supplement S10, pages 119–125, 2011
How to Cite
Monastyrskyy, B., Fidelis, K., Tramontano, A. and Kryshtafovych, A. (2011), Evaluation of residue–residue contact predictions in CASP9. Proteins, 79: 119–125. doi: 10.1002/prot.23160
- Issue published online: 9 NOV 2011
- Article first published online: 17 SEP 2011
- Accepted manuscript online: 24 AUG 2011 11:09AM EST
- Manuscript Accepted: 27 JUL 2011
- Manuscript Revised: 25 JUN 2011
- Manuscript Received: 6 MAY 2011
- National Library of Medicine (NIH/NLM). Grant Number: LM007085
- KAUST Award. Grant Number: KUK-I1-012-43
- intramolecular contacts;
- residue–residue contact prediction;
- protein structure modeling
This work presents the results of the assessment of the intramolecular residue–residue contact predictions submitted to CASP9. The methodology for the assessment does not differ from that used in previous CASPs, with two basic evaluation measures being the precision in recognizing contacts and the difference between the distribution of distances in the subset of predicted contact pairs versus all pairs of residues in the structure. The emphasis is placed on the prediction of long-range contacts (i.e., contacts between residues separated by at least 24 residues along sequence) in target proteins that cannot be easily modeled by homology. Although there is considerable activity in the field, the current analysis reports no discernable progress since CASP8. Proteins 2011; © 2011 Wiley-Liss, Inc.