The parts of the article on target T0629 were contributed by M.v.R., S.B., and J.O.; target T0605 by D.C. and C.K.; target T0531 by F.R., A.L., and J.B.; target T0543 by J.H., E.C., and A.P.; target T0561 by T.H. and A.P.; targets T0624 and T0555 by T.R., S.J., J.H., M.K., L.T., J.E., and G.M.; targets T0594 and T0566 by T.H., A.W., J.P., and R.H.; and target T0628 by K.M. and A.J. Editing, introduction, discussion, and coordination by A.K., J.M., and T.S..
Article first published online: 21 OCT 2011
Copyright © 2011 Wiley-Liss, Inc.
Proteins: Structure, Function, and Bioinformatics
Volume 79, Issue Supplement S10, pages 6–20, 2011
How to Cite
Kryshtafovych, A., Moult, J., Bartual, S. G., Bazan, J. F., Berman, H., Casteel, D. E., Christodoulou, E., Everett, J. K., Hausmann, J., Heidebrecht, T., Hills, T., Hui, R., Hunt, J. F., Seetharaman, J., Joachimiak, A., Kennedy, M. A., Kim, C., Lingel, A., Michalska, K., Montelione, G. T., Otero, J. M., Perrakis, A., Pizarro, J. C., van Raaij, M. J., Ramelot, T. A., Rousseau, F., Tong, L., Wernimont, A. K., Young, J. and Schwede, T. (2011), Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction. Proteins, 79: 6–20. doi: 10.1002/prot.23196
Evangelos Christodoulou's current address is MRC National Institute for Medical Research, Division of Molecular Structure, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
Andreas Lingel's current address is Novartis, Novartis Institutes for Biomedical Research, 4560 Horton Street, Emeryville, California 94608
Francois Rousseau's current address is NovImmune, SA, 14 ch. des Aulx, Plan-les-Ouates, CH 1228, Switzerland
J. Fernando Bazan's current address is NeuroScience, Inc., 373 280th St. Osceola, Wisconsin 54020
The authors state that AL was employed by Genentech.
- Issue published online: 9 NOV 2011
- Article first published online: 21 OCT 2011
- Accepted manuscript online: 15 SEP 2011 10:48AM EST
- National Library of Medicine (NIH/NLM). Grant Number: LM007085
- Spanish Ministry of Education and Science. Grant Number: BFU2008-01588
- European Commission. Grant Number: NMP4-CT-2006-033256
- Spanish Ministry of Education and Science (José Castillejo fellowship)
- Xunta de Galicia (Angeles Alvariño fellowship)
- National Institutes of Health. Grant Numbers: K22-CA124517, R01-GM090161, GM074942, GM094585
- U. S. Department of Energy, Office of Biological and Environmental Research. Grant Number: DE-AC02-06CH11357
- Foundation for Polish Science (to K.M.)
- NSF. Grant Number: DBI 0829586
- protein structure;
- X-ray crystallography;
- structure prediction
One goal of the CASP community wide experiment on the critical assessment of techniques for protein structure prediction is to identify the current state of the art in protein structure prediction and modeling. A fundamental principle of CASP is blind prediction on a set of relevant protein targets, that is, the participating computational methods are tested on a common set of experimental target proteins, for which the experimental structures are not known at the time of modeling. Therefore, the CASP experiment would not have been possible without broad support of the experimental protein structural biology community. In this article, several experimental groups discuss the structures of the proteins which they provided as prediction targets for CASP9, highlighting structural and functional peculiarities of these structures: the long tail fiber protein gp37 from bacteriophage T4, the cyclic GMP-dependent protein kinase Iβ dimerization/docking domain, the ectodomain of the JTB (jumping translocation breakpoint) transmembrane receptor, Autotaxin in complex with an inhibitor, the DNA-binding J-binding protein 1 domain essential for biosynthesis and maintenance of DNA base-J (β-D-glucosyl-hydroxymethyluracil) in Trypanosoma and Leishmania, an so far uncharacterized 73 residue domain from Ruminococcus gnavus with a fold typical for PDZ-like domains, a domain from the phycobilisome core-membrane linker phycobiliprotein ApcE from Synechocystis, the heat shock protein 90 activators PFC0360w and PFC0270w from Plasmodium falciparum, and 2-oxo-3-deoxygalactonate kinase from Klebsiella pneumoniae. Proteins 2011; © 2011 Wiley-Liss, Inc.