The authors state no conflict of interest.
CASP Introduction—Round IX
Critical assessment of methods of protein structure prediction (CASP)—round IX †
Article first published online: 14 OCT 2011
Copyright © 2011 Wiley-Liss, Inc.
Proteins: Structure, Function, and Bioinformatics
Volume 79, Issue Supplement S10, pages 1–5, 2011
How to Cite
Moult, J., Fidelis, K., Kryshtafovych, A. and Tramontano, A. (2011), Critical assessment of methods of protein structure prediction (CASP)—round IX . Proteins, 79: 1–5. doi: 10.1002/prot.23200
- Issue published online: 9 NOV 2011
- Article first published online: 14 OCT 2011
- Accepted manuscript online: 19 SEP 2011 05:23AM EST
- Manuscript Accepted: 12 SEP 2011
- Manuscript Received: 7 SEP 2011
- National Library of Medicine. Grant Number: LM07085
- NIH Institute of General Medical Sciences. Grant Number: GM072354
- KAUST Award. Grant Number: KUK-I1-012-43
- protein structure prediction;
- community wide experiment;
This article is an introduction to the special issue of the journal PROTEINS, dedicated to the ninth Critical Assessment of Structure Prediction (CASP) experiment to assess the state of the art in protein structure modeling. The article describes the conduct of the experiment, the categories of prediction included, and outlines the evaluation and assessment procedures. Methods for modeling protein structure continue to advance, although at a more modest pace than in the early CASP experiments. CASP developments of note are indications of improvement in model accuracy for some classes of target, an improved ability to choose the most accurate of a set of generated models, and evidence of improvement in accuracy for short “new fold” models. In addition, a new analysis of regions of models not derivable from the most obvious template structure has revealed better performance than expected. Proteins 2011; © 2011 Wiley-Liss, Inc.