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Additional Supporting Information may be found in the online version of this article.

FilenameFormatSizeDescription
PROT_24143_sm_SuppFig1.pdf470KSupporting Information Figure S1: Scatter-plot matrix of ten parameters for an EF-hand: Lower left triangle, scatter plots Upper right triangle, correlation coefficient, R, of each plot Parameter names are shown in boxes at diagonal. From top, dE(theta) (elevation of the E-helix), dE(phi) (azimuth of the helix E), dF(theta) (elevation of helix F), dF(phi) (azimuth of helix F), oE(L) (length of offset vector for helix E), oE(theta) (elevation off offset vector for helix E), oE(phi) (azimuth of offset vector for helix E), oF(L) (length of offset vector for helix F), oF(theta) (elevation of offset vector for helix F), and oF(phi) (azimuth of offset vector for helix F). The four critical parameters - dE(theta), dE(phi), dF(theta), dF(phi) – are shown in Figure 3. Scatter plots closed diamond or triangle, apo-form; open diamond or triangle, calci-form; diamond, no target; triangle, target-bound red, odd domain in N-lobe; blue even domain in N-lobe black, odd domain in C-lobe; purple, even domain in C-lobe.
PROT_24143_sm_SuppFig2.pdf33KSupporting Information Figure S2: Dendrogram for N-lobes of EF-hands of four domain structures including CTER: Ca, + red, - blue; target, + lime, - black; odd, lime; even, black Subfamily: AEQ, maroon; CDC, red; CDPK, olive; CIB, green; CLNB, lime; CVP, teal; LAV, aqua; P22, navy; SARC, blue; SOS3, purple ;VIS, fuchsia As in Figure 6 that showed only EF-hands from CTER, the calci-forms cluster together as do the semi-open-forms; both are distinct from the apo-forms of the EF-hand.
PROT_24143_sm_SuppFig3.pdf32KSupporting Information Figure S3: Dendrogram for the C-lobes of EF-hands of four domain structures including CTER: Ca, + red, - blue; target, + lime, - black; odd, lime; even, black Subfamily: AEQ, maroon; CDC, red; CDPK, olive; CIB, green; CLNB, lime; CVP, teal; LAV, aqua; P22, navy; SARC, blue; SOS3, purple; VIS, fuchsia As in Figure 6 that showed only EF-hands from CTER, the calci-forms cluster together as do the semi-open-forms; both are distinct from the apo-forms of the EF-hand.
PROT_24143_sm_SuppTab1.pdf167KSupporting Information Table 1.
PROT_24143_sm_SuppTab2.pdf82KSupporting Information Table 2.

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