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Keywords:

  • Gaussian Network Model;
  • allosteric communication;
  • allostery;
  • contact matrix;
  • residue fluctuations;
  • glutamine amidotransferase

ABSTRACT

Fluctuations of the distance between a pair of residues i and j may be correlated with the fluctuations of the distance between another pair k and l. In this case, information may be transmitted among these four residues. Allosteric activity is postulated to proceed through such correlated paths. In this short communication a fast method for calculating correlations among all possible pairs ij and kl leading to a pathway of correlated residues of a protein is proposed. The method is based on the alpha carbon centered Gaussian Network Model. The model is applied to Glutamine Amidotransferase and pathways of allosteric activity are identified and compared with literature. Proteins 2013; 81:1097–1101. © 2013 Wiley Periodicals, Inc.