Get access
Advertisement

Protein misfolding in the late-onset neurodegenerative diseases: Common themes and the unique case of amyotrophic lateral sclerosis

Authors

  • Vikram Khipple Mulligan,

    1. Department of Biochemistry, University of Washington, Seattle, Washington
    Search for more papers by this author
  • Avijit Chakrabartty

    Corresponding author
    1. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M5G 1L7, Canada
    2. Campbell Family Institute for Cancer Research, Ontario Cancer Institute/University Health Network, Toronto, Ontario, Canada
    • Department of Biochemistry, Toronto, Ontario, Canada
    Search for more papers by this author

Correspondence to: Dr. Avijit Chakrabartty, Toronto Medical Discovery Tower, 4th floor, room 4-307, MaRS Building, 101 College Street, Toronto, ON, M5G 1L7, Canada.  E-mail:  chakrab@uhnres.utoronto.ca

ABSTRACT

Enormous strides have been made in the last 100 years to extend human life expectancy and to combat the major infectious diseases. Today, the major challenges for medical science are age-related diseases, including cancer, heart disease, lung disease, renal disease, and late-onset neurodegenerative disease. Of these, only the neurodegenerative diseases represent a class of disease so poorly understood that no general strategies for prevention or treatment exist. These diseases, which include Alzheimer's disease, Parkinson's disease, Huntington's disease, the transmissible spongiform encephalopathies, and amyotrophic lateral sclerosis (ALS), are generally fatal and incurable. The first section of this review summarizes the diversity and common features of the late-onset neurodegenerative diseases, with a particular focus on protein misfolding and aggregation—a recurring theme in the molecular pathology. The second section focuses on the particular case of ALS, a late-onset neurodegenerative disease characterized by the death of central nervous system motor neurons, leading to paralysis and patient death. Of the 10% of ALS cases that show familial inheritance (familial ALS), the largest subset is caused by mutations in the SOD1 gene, encoding the Cu, Zn superoxide dismutase (SOD1). The unusual kinetic stability of SOD1 has provided a unique opportunity for detailed structural characterization of conformational states potentially involved in SOD1-associated ALS. This review discusses past studies exploring the stability, folding, and misfolding behavior of SOD1, as well as the therapeutic possibilities of using detailed knowledge of misfolding pathways to target the molecular mechanisms underlying ALS and other neurodegenerative diseases. Proteins 2013; 81:1285–1303. © 2013 Wiley Periodicals, Inc.

Get access to the full text of this article

Ancillary