The U.S. Chemical Safety and Hazard Investigation Board (CSB) began operations as an independent federal agency in 1998. Its primary mission is to prevent chemical-related incidents (fires, explosions, or toxic releases) in commercial or industrial settings by conducting incident investigations, reporting on causes, and issuing safety recommendations. This paper discusses some findings of the reactive chemical hazard investigation that originated from CSB's investigation of a runaway reaction at Morton International in 1998. As a result of this investigation, the Board made recommendations to promote the safe handling of reactive chemicals. Incident data sources were surveyed to determine the number and impact of reactive chemical incidents. Through site visits and surveys, the Board gathered information about reactive chemical hazard management for select small, medium, and large companies within the chemical industry. OSHA and EPA were also surveyed to determine current regulatory approaches for managing reactive chemical hazards and to identify future agency plans. This paper focuses on evidence that supports the Board's findings and recommendations on improving reactive chemical process safety.