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Acute toxicity to zebrafish of two organophosphates and four pyrethroids and their binary mixtures

Authors

  • Zhi-Yong Zhang,

    1. Institute of Food Safety Research and Inspection, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu, China
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  • Xiang-Yang Yu,

    1. Institute of Food Safety Research and Inspection, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu, China
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  • Dong-Lan Wang,

    1. Institute of Food Safety Research and Inspection, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu, China
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  • Hai-Juan Yan,

    1. Institute of Food Safety Research and Inspection, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu, China
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  • Xian-Jin Liu

    Corresponding author
    1. Institute of Food Safety Research and Inspection, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu, China
    • Institute of Food Safety Research and Inspection, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu 210014, PR China.
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Abstract

BACKGROUND: Environmental pollutants, including metals, pesticides and other organics, pose serious risks to many aquatic organisms. The acute toxicities to zebrafish (Brachydanio rerio Hamilton & Buchanan) were determined for two organophosphorus insecticides, four pyrethroid insecticides and 50:50 binary mixtures.

RESULTS: At 24, 48, 72 and 96 h after treatment, LC50 of permethrin, tetramethrin, bifenthrin, etofenprox, dichlorvos and phoxim to zebrafish were 0.0052–0.0025, 0.0782–0.0460, 0.0065–0.0032, 0.0969–0.0791, 51.3–13.0 and 1.28–0.469 mg L−1 respectively. LC50 of permethrin + dichlorvos, permethrin + phoxim, tetramethrin + dichlorvos, tetramethrin + phoxim, bifenthrin + dichlorvos, bifenthrin + phoxim, etofenprox + dichlorvos and etofenprox + phoxim were 0.0082–0.0046, 0.0078–0.0042, 0.264–0.124, 0.141–0.121, 0.0251–0.0154, 0.0154–0.0087, 0.396–0.217 and 0.213–0.0391 mg L−1.

CONCLUSION: Toxicity levels of all pyrethroid insecticides to the zebrafish were high or very high. The organophosphate dichlorvos showed low toxicity, but phoxim showed high or intermediate toxicities to zebrafish, and the toxicities of binary mixtures of permethrin and dichlorvos or phoxim, bifenthrin and dichlorvos or phoxim and etofenprox and phoxim (48, 72 and 96 h exposure) were very high. The toxicities of binary mixtures of tetramethrin and dichlorvos or phoxim, etofenprox and dichlorvos and etofenprox and phoxim (24 h exposure) were high. Copyright © 2009 Society of Chemical Industry

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