Based on a paper presented at the meeting ‘Anticoagulant Resistance: Distribution, Testing Methods, Mechanisms and Management’ organised by the GIFAP/ECPA Rodenticide Resistance Action Committee (RRAC) and held in Monheim, Germany on 2 April 1993.
Resistance to anticoagulant rodenticides in Germany and future strategies to control Rattus norvegicus†
Article first published online: 8 MAY 2006
Copyright © 1995 John Wiley & Sons, Ltd
Volume 43, Issue 1, pages 61–67, January 1995
How to Cite
Pelz, H.-J., Hänisch, D. and Lauenstein, G. (1995), Resistance to anticoagulant rodenticides in Germany and future strategies to control Rattus norvegicus. Pestic. Sci., 43: 61–67. doi: 10.1002/ps.2780430110
- Issue published online: 8 MAY 2006
- Article first published online: 8 MAY 2006
- Manuscript Accepted: 12 SEP 1994
- Manuscript Revised: 11 JUN 1994
- Manuscript Received: 21 MAR 1994
- Rattus norvegicus;
- control strategy;
Widespread anticoagulant resistance was discovered in populations of the brown rat (Rattus norvegicus Berk.) in an area of roughly 8000 km2 in north-west Germany. Resistance testing was performed by feeding tests and/or by measuring blood clotting response after intraperitoneal injection of a sublethal testing solution. A hierarchical resistance system was found with warfarin resistance at the base followed by bromadiolone/coumatetralyl resistance to difenacoum resistance at the top. Warfarin resistance was spread over the whole area with reduced incidence towards the edges. Difenacoum resistance represented the highest level found so far and was restricted to the inner zone of the resistance area where it occurred with a frequency of 6% of all individuals tested.
Breeding experiments with bromadiolone-resistant rats showed that expression of the bromadiolone resistance gene differed in the two sexes, suggesting additional sex-linked modifying effects to the resistance gene. Control strategy within the resistance area with respect to prevention of further selection for resistance is discussed.