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New formulation of paraquat with lysine acetylsalicylate with low mammalian toxicity and effective herbicidal activity

Authors

  • Maria Teresa Baltazar,

    Corresponding author
    1. REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal
    2. Department of Sciences, Advanced Institute of Health Sciences – North, CESPU, CRL, Gandra, Portugal
    • Correspondence to: Maria Teresa Baltazar and Félix Carvalho, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto Porto, Portugal. E-mails: mteresabaltazar@gmail.com; felixdc@ff.up.pt

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  • Ricardo Jorge Dinis-Oliveira,

    1. REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal
    2. Department of Sciences, Advanced Institute of Health Sciences – North, CESPU, CRL, Gandra, Portugal
    3. Department of Legal Medicine and Forensic Sciences, Faculty of Medicine, University of Porto, Porto, Portugal
    4. Department of Clinical Analysis and Public Health, Polytechnic Health Institute of the North CRL, Vila Nova de Famalicão, Portugal
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  • Lúcia Guilhermino,

    1. CIIMAR – Interdisciplinary Centre of Marine and Environmental Research, Laboratory of Ecotoxicology and Ecology, Porto, Portugal
    2. ICBAS – Institute of Biomedical Sciences of Abel Salazar, University of Porto, Department of Population Studies, Laboratory of Ecotoxicology, Porto, Portugal
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  • Maria de Lourdes Bastos,

    1. REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal
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  • José Alberto Duarte,

    1. CIAFEL, Faculty of Sports, University of Porto, Porto, Portugal
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  • Félix Carvalho

    Corresponding author
    1. REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal
    • Correspondence to: Maria Teresa Baltazar and Félix Carvalho, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto Porto, Portugal. E-mails: mteresabaltazar@gmail.com; felixdc@ff.up.pt

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  • Portuguese provisional patent N°20121000028929

Abstract

Background

Currently, the commercial formulations of the herbicide paraquat are highly toxic to humans, and no effective antidote is available for paraquat poisoning. The aim of the present study was to develop a safe formulation, combining paraquat and the known antidote lysine acetylsalicylate. The toxicity of a mixture of Gramoxone® (20% paraquat) and lysine acetylsalicylate in adult Wistar male rats and the herbicidal efficacy against grass lawn (50% of Poa pratensis and 50% of Festuca arundinacea) were evaluated. This new formulation was administered to Wistar rats by gavage at 125 mg kg−1 of paraquat ion and lysine acetylsalicylate at 79, 158 or 316 mg kg−1 body weight, and the survival rate was observed for 30 days.

Results

The survival rate of the paraquat group was only 40%, while lysine acetylsalicylate provided effective protection, with full survival observed in the groups that received 125 mg kg−1 of paraquat ion and 316 mg kg−1 of lysine acetylsalicylate. Both formulations of paraquat, either in the absence or in the presence of lysine acetylsalicylate, provided the same herbicidal activity against the tested herbal species.

Conclusions

The present formulation of paraquat containing lysine acetylsalicylate, significantly decreases mammalian toxicity while maintaining effective herbicidal activity. © 2012 Society of Chemical Industry

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