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Keywords:

  • Dichloro-allyloxy-phenol derivatives;
  • pyrazole;
  • insecticidal activities;
  • structure–activity relationship

Abstract

BACKGROUND

Pyridalyl, consisting of dicholoro-allyoxy-phenol moiety, is a novel class of insecticide showing extraordinary activities against various lepidopterous and thysanopterous pests on cotton and vegetables. To discover further novel insecticides, a series of new dichloro-allyloxy-phenol derivatives containing substituted pyrazol-3-ol moieties were designed and synthesised via the intermediate derivatisation method.

RESULTS

The target compounds were characterised by 1H NMR, IR, MS and elemental analysis. Bioassays indicated that some of these compounds exhibited good insecticidal activities against diamondback moth (Plutella xylostella) at 6.25 mg L−1. The structure–activity relationship is discussed.

CONCLUSION

The present work demonstrates that dichloro-allyloxy-phenol derivatives with substituted phenylpyrazole moieties can be used as lead compounds to develop further novel insecticides.© 2012 Society of Chemical Industry