Synthesis and antifeedant activity of novel alpha-asarone derivatives against stored-product pests


Correspondence to: Bozena Łozowicka, Plant Protection Institute – National Research Institute, Regional Experimental Station, 22 Chełmońskiego St., 15-195 Białystok, Poland. E-mail:



Alpha-asarone (2,4,5-trimethoxypropenylbenzene) derivatives represent a new series of compounds that possess good antifeedant activity against different stored-product pests.


A total of 23 novel alpha-asarone derivatives were synthesised and identified by 1H NMR, 13C NMR and IR, and their feeding deterrent activities were tested against Sitophilus granarius L., Trogoderma granarium Ev. and Tribolium confusum Duv. Ten compounds showed strong antifeedant activities.


Some of the title compounds displayed very good and broad-spectrum activities against adult and larval Coleoptera. The results indicate that the presence of a double bond in the side chain and three methoxy groups is important for antifeedant activity. © 2012 Society of Chemical Industry