Acaricidal activities of β-caryophyllene oxide and structural analogues derived from Psidium cattleianum oil against house dust mites

Authors

  • Min-Seok Oh,

    1. Department of Bioenvironmental Chemistry and Institute of Agricultural Science and Technology, College of Agriculture and Life Sciences, Chonbuk National University, Jeonju, South Korea
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  • Ji-Yeon Yang,

    1. Department of Bioenvironmental Chemistry and Institute of Agricultural Science and Technology, College of Agriculture and Life Sciences, Chonbuk National University, Jeonju, South Korea
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  • Min-Gi Kim,

    Corresponding author
    1. Department of Bioenvironmental Chemistry and Institute of Agricultural Science and Technology, College of Agriculture and Life Sciences, Chonbuk National University, Jeonju, South Korea
    • Correspondence to: Prof. Dr Hoi-Seon Lee and Dr Min-Gi Kim, Department of Bioenvironmental Chemistry, College of Agriculture and Life Sciences, Chonbuk National University, Jeonju 561–756, South Korea. Tel: +82-63-270-2544; Fax: +82-63-270-2550. E-mail: hoiseon@jbnu.ac.kr and mingi21c@jbnu.ac.kr

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  • Hoi-Seon Lee

    Corresponding author
    1. Department of Bioenvironmental Chemistry and Institute of Agricultural Science and Technology, College of Agriculture and Life Sciences, Chonbuk National University, Jeonju, South Korea
    • Correspondence to: Prof. Dr Hoi-Seon Lee and Dr Min-Gi Kim, Department of Bioenvironmental Chemistry, College of Agriculture and Life Sciences, Chonbuk National University, Jeonju 561–756, South Korea. Tel: +82-63-270-2544; Fax: +82-63-270-2550. E-mail: hoiseon@jbnu.ac.kr and mingi21c@jbnu.ac.kr

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Abstract

BACKGROUND

This study was to evaluate the acaricidal activities of an active compound isolated from Psidium cattleianum and structural analogues against Dermatophagoides farinae and D. pteronyssinus. β-Caryophyllene oxide was isolated using chromatographic techniques.

RESULTS

Based on the 50% lethal concentration (LD50) values against D. farinae using the fumigant method, β-caryophyllene oxide (1.36 µg cm−2) was ∼ 7.52 times more toxic than benzyl benzoate (10.23 µg cm−2), followed by α-caryophyllene (1.75 µg cm−2) and β-caryophyllene (3.13 µg cm−2). Against D. pteronyssinus, β-caryophyllene oxide (1.38 µg cm−2) was ∼ 7.22 times more toxic than benzyl benzoate (9.96 µg cm−2), followed by α-caryophyllene (1.71 µg cm−2) and β-caryophyllene (3.58 µg cm−2). In the contact toxicity method against D. farinae, β-caryophyllene oxide (0.44 µg cm−2) was ∼ 17.27 times more active than benzyl benzoate (7.60 µg cm−2), followed by α-caryophyllene (0.67 µg cm−2) and β-caryophyllene (0.91 µg cm−2). Against D. pteronyssinus, β-caryophyllene oxide (0.47 µg cm−2) was ∼ 13.06 times more effective than benzyl benzoate (6.14 µg cm−2), followed by α-caryophyllene (1.71 µg cm−2) and β-caryophyllene (3.58 µg cm−2).

CONCLUSION

β-Caryophyllene oxide and structural analogues have potential for development as preventive agents for the control of house dust mites. © 2013 Society of Chemical Industry

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