Evolution of resistance to phytoene desaturase and protoporphyrinogen oxidase inhibitors – state of knowledge

Authors

  • Franck E Dayan,

    Corresponding author
    1. Natural Products Utilization Research Unit, United States Department of Agriculture – Agricultural Research Service, University, MS, USA
    • Correspondence to: Franck E Dayan, Natural Products Utilization Research Unit, United States Department of Agriculture – Agricultural Research Service, PO Box 8048, University, MS 38677, USA. E-mail: Franck.Dayan@ars.usda.gov

    Search for more papers by this author
  • Daniel K Owens,

    1. Natural Products Utilization Research Unit, United States Department of Agriculture – Agricultural Research Service, University, MS, USA
    Search for more papers by this author
  • Patrick J Tranel,

    1. Department of Crop Sciences, University of Illinois, Urbana, IL, USA
    Search for more papers by this author
  • Christopher Preston,

    1. School of Agriculture, Food and Wine, The University of Adelaide, Glen Osmond, Adelaide, SA, Australia
    Search for more papers by this author
  • Stephen O Duke

    1. Natural Products Utilization Research Unit, United States Department of Agriculture – Agricultural Research Service, University, MS, USA
    Search for more papers by this author

Abstract

Two major classes of herbicides include inhibitors of protoporphyrinogen oxidase (PPO) and phytoene desaturase (PDS). Plants can evolve resistance to PPO and PDS inhibitors via several mechanisms that include physical changes, resulting in reduced uptake, physiological changes, resulting in compartmentalization or altered translocation, and biochemical changes, resulting in enhanced metabolic degradation or alterations of protein structures, leading to loss of sensitivity to the herbicides. This review discusses the involvement of some of these mechanisms in the various cases of resistance to PDS- and PPO-inhibiting herbicides, and highlights unique aspects of target-site resistance to these herbicides. © 2014 Society of Chemical Industry

Ancillary