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Keywords:

  • acaricidal agent;
  • acaricidal effect;
  • camphor;
  • Dermatophagoides farinae;
  • Dermatophagoides pteronyssinus;
  • structural analogues

Abstract

BACKGROUND

The acaricidal activities of (±)-camphor structural analogues against house dust mites were evaluated using the impregnated fabric disc bioassay.

RESULTS

The acaricidal effects of camphor and its structural analogues were evaluated against Dermatophagoides farinae and D. pteronyssinus. Based on the LD50 values against D. farinae, (±)-camphor (0.95 µg cm−2) was 38.75 times more effective than N,N-diethyl-m-toluamide (DEET) (36.81 µg cm−2), followed by (+)-camphor (1.41 µg cm−2), (−)-camphor (2.03 µg cm−2) and (1R)-camphor oxime (3.31 µg cm−2) in the impregnated fabric disc bioassay. However, camphor-10-sulfonic acid and camphoric acid had no observable activity against D. farinae or D. pteronyssinus. The acaricidal activities of camphor and its structural analogues against D. pteronyssinus were similar to those against D. farinae.

CONCLUSION

These results indicate that camphor and its structural analogues are suitable for producing acaricidal agents against house dust mites. © 2014 Society of Chemical Industry