A room temperature ionic liquid as convenient solvent for the oxidative folding of conopeptides
Article first published online: 16 DEC 2008
Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.
Journal of Peptide Science
Volume 15, Issue 2, pages 72–77, February 2009
How to Cite
Miloslavina, A. A., Leipold, E., Kijas, M., Stark, A., Heinemann, S. H. and Imhof, D. (2009), A room temperature ionic liquid as convenient solvent for the oxidative folding of conopeptides. J. Peptide Sci., 15: 72–77. doi: 10.1002/psc.1106
- Issue published online: 9 JAN 2009
- Article first published online: 16 DEC 2008
- Manuscript Accepted: 11 NOV 2008
- Manuscript Revised: 10 NOV 2008
- Manuscript Received: 27 OCT 2008
- Deutsche Forschungsgemeinschaft HE2993/5 (S. H. H.)
- Carl-Zeiss-Stiftung, S.T.I.F.T.
- Friedrich Schiller University Jena (A.S. and D.I.)
- cysteine-rich peptides;
- oxidative folding;
- ionic liquids
We report the first example of conopeptide oxidation performed in a biocompatible ionic liquid, 1-ethyl-3-methylimidazolium acetate ([C2mim][OAc]), which enables the efficient formation of both hydrophilic and poorly water-soluble conotoxins compared with conventional methods. Moreover, the method features a high-concentration approach ultimately leading to higher yields at reduced separation effort. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.