Special issue devoted to contributions presented at the E-MRS Symposium C “Peptide-based materials: from nanostructures to applications”, 7-11 June 2010, Strasbourg, France.
Version of Record online: 20 SEP 2010
Copyright © 2010 European Peptide Society and John Wiley & Sons, Ltd.
Journal of Peptide Science
Special Issue: Peptide-based materials: from nanostructures to applications
Volume 17, Issue 2, pages 139–142, February 2011
How to Cite
Gaillard, C., Duval, M., Dumortier, H. and Bianco, A. (2011), Carbon nanotube-coupled cell adhesion peptides are non-immunogenic: a promising step toward new biomedical devices. J. Peptide Sci., 17: 139–142. doi: 10.1002/psc.1290
This article is dedicated to the 70th birthday of Professor Claudio Toniolo.
- Issue online: 13 JAN 2011
- Version of Record online: 20 SEP 2010
- Manuscript Revised: 3 AUG 2010
- Manuscript Accepted: 3 AUG 2010
- Manuscript Received: 2 AUG 2010
- European Union
- NEURONANO program. Grant Number: NMP4-CT-2006-031847
- carbon nanotubes;
Carbon nanotubes functionalized with cell adhesion peptides can be considered as novel, promising candidates for the development of advanced drug delivery systems or for designing new generation of self-assembling nerve ‘bridges’. An important step toward the integration of these types of conjugates in living bodies is the assessment of their impact on the immune system. In this direction, an integrin-derived peptide has been covalently conjugated to carbon nanotubes. Following intraperitoneal administration, peptide–carbon nanotubes do not trigger an anti-peptide antibody production. Demonstration of the immune neutrality of peptide–carbon nanotubes reinforces their potential use as substrates for neuronal regeneration in vivo. Copyright © 2010 European Peptide Society and John Wiley & Sons, Ltd.