Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400005, India.
Synthesis and self-assembly of a neoglycopeptide: morphological studies and ultrasound-mediated DNA encapsulation†
Article first published online: 28 DEC 2010
Copyright © 2010 European Peptide Society and John Wiley & Sons, Ltd.
Journal of Peptide Science
Special Issue: Peptide-based materials: from nanostructures to applications
Volume 17, Issue 2, pages 148–153, February 2011
How to Cite
Gour, N., Mondal, S. and Verma, S. (2011), Synthesis and self-assembly of a neoglycopeptide: morphological studies and ultrasound-mediated DNA encapsulation. J. Peptide Sci., 17: 148–153. doi: 10.1002/psc.1334
Special issue devoted to the E-MRS Symposium C “Peptide-based materials: from nanostructures to applications”, 7–11 June 2010, Strasbourg, France.
- Issue published online: 13 JAN 2011
- Article first published online: 28 DEC 2010
- Manuscript Accepted: 25 OCT 2010
- Manuscript Revised: 23 OCT 2010
- Manuscript Received: 6 SEP 2010
- Department of Science and Technology, India (SV)
- DNA encapsulation
Self-assembly in peptides and proteins is an often encountered concept, where constituent building blocks are recruited and stabilized, via carefully orchestrated hydrophobic interactions, hydrogen bonding and other non-covalent interactions, to eventually reveal an array of supramolecular aggregates, with defined structural features. This study presents synthesis and self-assembly of a mannosylated peptide in aqueous medium. Turbidimetric assay with Concanavalin A (Con A), a mannose binding protein, was conducted to confirm the presence of hydrophilic mannose group on the exterior surface of self-assembled structures. DNA encapsulation in these soft structures was achieved by ultrasonication of soft spherical structures in the presence of plasmid DNA. Copyright © 2010 European Peptide Society and John Wiley & Sons, Ltd.