Solid phase synthesis of peptide hydroxamic acids on poly(ethylene glycol)-based support

Authors


Piotr Stefanowicz, Institute Chemistry, University of Wrocław, 50-383, Joliot-Curie 14, Wrocław, Poland. E-mail: piotr.stefanowicz@chem.uni.wroc.pl

Abstract

A novel resin designed for solid-phase synthesis of peptide hydroxamic acids (PHA) combining the trityl linker with poly(ethylene glycol)-based support, ChemMatrix® type, is described. The synthesis of PHA can be performed according to a standard protocol, providing products in excellent purity and reasonable yields. Copyright © 2012 European Peptide Society and John Wiley & Sons, Ltd.

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