Selected paper presented at the 1st International Congress on Natural Peptides to Drugs, 30 November–3 December 2004, Zermatt, Switzerland.
Novel lysine-peptoid hybrids with antibacterial properties†
Article first published online: 13 SEP 2005
Copyright © 2005 European Peptide Society and John Wiley & Sons, Ltd.
Journal of Peptide Science
Special Issue: 1st International Congress on Natural Peptides to Drugs (NP2D), 2004, Zermatt, Switzerland
Volume 11, Issue 11, pages 727–734, November 2005
How to Cite
Ryge, T. S. and Hansen, P. R. (2005), Novel lysine-peptoid hybrids with antibacterial properties. J. Peptide Sci., 11: 727–734. doi: 10.1002/psc.705
- Issue published online: 7 OCT 2005
- Article first published online: 13 SEP 2005
- Manuscript Accepted: 26 APR 2005
- Manuscript Revised: 23 MAR 2005
- Manuscript Received: 20 JAN 2005
- Danish Research Council. Grant Number: 9900234
- Augustinus Foundation
- Frimodt–Heineke Foundation
- Niels Hansens Legat
- Family Hede Nielsen Foundation
- Aase & Ejnar Danielsens Foundation
- antimicrobial peptides;
- lysine-peptoid hybrids;
- solid-phase peptide synthesis
Here we report the design, synthesis and antibacterial activity of 20 lysine-peptoid hybrids. The hybrids are based on the peptoid lead structure [N-(1-naphthalenemethyl)glycyl]-[N-(4-methylbenzyl)glycyl]-[N-(1-naphthalenemethyl)glycyl]-N-(butyl)glycin amide (1) and contain between one and six lysine residues each. The compounds were tested for antibacterial activity against S. aureus ATCC 25923 and E. coli ATCC 25922. Furthermore, the hemolytic activity toward human erythrocytes was assessed. Several compounds with potent antibacterial activity and low hemolytic activity were identified. Copyright © 2005 European Peptide Society and John Wiley & Sons, Ltd.