Identification of a novel antitumor peptide based on the screening of an Ala-library derived from the LALF32–51 region (pages 40–47)
Maribel G. Vallespi, Julio R. Fernandez, Isis Torrens, Isbel Garcia, Hilda Garay, Osmani Mendoza, Milaid Granadillo, Viviana Falcon, Boris Acevedo, Raimundo Ubieta, Gerardo E. Guillen and Osvaldo Reyes
Article first published online: 11 NOV 2009 | DOI: 10.1002/psc.1192
By modifying the primary structure of the Limulus-derived LALF32–51 peptide we designed a novel peptide with antineoplastic effect and cell-penetrating capacity. This new peptide may serve as the prototype of a peptide-based drug with potential applicability in the cancer therapy.