Interaction of a β-sheet breaker peptide with lipid membranes (pages 115–122)
Giuseppe Vitiello, Manuela Grimaldi, Anna Ramunno, Ornella Ortona, Giovanni De Martino, Anna Maria D'Ursi and Gerardino D'Errico
Article first published online: 8 JAN 2010 | DOI: 10.1002/psc.1207
The β-sheet breaker peptide iAβ5p interacts with phospholipid membranes and this interaction is modulated by inclusion of cholesterol in the bilayer formulation. Particularly, cholesterol decreases the peptide partition coefficient between the membrane and the aqueous medium. Moreover, in the presence of cholesterol the peptide penetrates more deeply into the lipid bilayer.