Journal of Peptide Science

Cover image for Journal of Peptide Science

April 2010

Volume 16, Issue 4

Pages 165–211

  1. Research Articles

    1. Top of page
    2. Research Articles
    1. Solution structure of LC5, the CCR5- derived peptide for HIV-1 inhibition (pages 165–170)

      Kazuhide Miyamoto, Kayo Togiya, Ryo Kitahara, Kazuyuki Akasaka and Yoshihiro Kuroda

      Version of Record online: 1 MAR 2010 | DOI: 10.1002/psc.1215

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      The synthetic peptide LC5 inhibits human immunodeficiency virus type 1 (HIV-1) infection of MT-4 cells. The solution structure of LC5 in SDS micelles was elucidated by using NMR method along with circular dichroism and fluorescence quenching. The peptide adopts the α1 helical structure in the C-terminal region (residues 13–16), whereas the N-terminal part remains unstructured.

    2. Structure-activity relationship of indolicidin, a Trp-rich antibacterial peptide (pages 171–177)

      Setsuko Ando, Keitarou Mitsuyasu, Yoshitake Soeda, Mariko Hidaka, Yuki Ito, Kouki Matsubara, Mitsuno Shindo, Yoshiki Uchida and Haruhiko Aoyagi

      Version of Record online: 1 MAR 2010 | DOI: 10.1002/psc.1217

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      A series of Trp and Arg analogs of antibacterial indolicidin (Ind) was synthesized and the antimicrobial and hemolytic activities were investigated. Important Trp residues in Ind for these activities were clarified. A retro analog exhibited lower hemolytic activity than that of Ind.

    3. Novel method for the synthesis of urea backbone cyclic peptides using new Alloc-protected glycine building units (pages 178–185)

      Mattan Hurevich, Yftah Tal-Gan, Shoshana Klein, Yaniv Barda, Alexander Levitzki and Chaim Gilon

      Version of Record online: 1 MAR 2010 | DOI: 10.1002/psc.1218

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      We have prepared new crystalline Fmoc-[N-(Alloc)ω-aminoalkyl]glycine building units especially suitable for backbone cyclic peptide synthesis. These building units were used to synthesize four urea backbone cyclic PKB/Akt peptide inhibitors by standard Fmoc SPPS procedures.

    4. Studies of insect peptides alloferon, Any-GS and their analogues. Synthesis and antiherpes activity (pages 186–189)

      Mariola Kuczer, Katarzyna Dziubasik, Anna Midak-Siewirska, Renata Zahorska, Mirosław Łuczak and Danuta Konopińska

      Version of Record online: 26 FEB 2010 | DOI: 10.1002/psc.1219

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      In preliminary investigations we found that alloferon, Any-GS and their analogues inhibited to a high degree the replication of HHV-1 in Vero cells.

    5. Synthesis of disulfated peptides corresponding to the N-terminus of chemokines receptors CXCR6 (CXCR61–20) and DARC (DARC8–42) using a sulfate-protecting group strategy (pages 190–199)

      Ahmed M. Ali and Scott D. Taylor

      Version of Record online: 1 MAR 2010 | DOI: 10.1002/psc.1220

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      Disulfated peptides corresponding to the N-terminus of chemokines receptors CXCR6 and DARC were prepared using Fmoc-based solid phase synthesis in which the sulfate groups in the sulfotyrosine residues were introduced as a DCV-protected sulfodiesters.

    6. An optimized chemical synthesis of human relaxin-2 (pages 200–211)

      Kostas K. Barlos, Dimitrios Gatos, Zoe Vasileiou and Kleomenis Barlos

      Version of Record online: 26 FEB 2010 | DOI: 10.1002/psc.1221

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      The random combination of the bicyclic human relaxin A-chain with the relaxin B-chain occurs in good yield and outstanding selectivity.

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