Structure-activity relationship of indolicidin, a Trp-rich antibacterial peptide (pages 171–177)
Setsuko Ando, Keitarou Mitsuyasu, Yoshitake Soeda, Mariko Hidaka, Yuki Ito, Kouki Matsubara, Mitsuno Shindo, Yoshiki Uchida and Haruhiko Aoyagi
Version of Record online: 1 MAR 2010 | DOI: 10.1002/psc.1217
A series of Trp and Arg analogs of antibacterial indolicidin (Ind) was synthesized and the antimicrobial and hemolytic activities were investigated. Important Trp residues in Ind for these activities were clarified. A retro analog exhibited lower hemolytic activity than that of Ind.