Structure–activity relationship of a novel pentapeptide with cancer cell growth-inhibitory activity (pages 242–248)
Masakatsu Kamiya, Keisuke Oyauchi, Yoshinori Sato, Takuya Yokoyama, Mofei Wang, Tomoyasu Aizawa, Yasuhiro Kumaki, Mineyuki Mizuguchi, Kunio Imai, Makoto Demura, Koichi Suzuki and Keiichi Kawano
Version of Record online: 12 APR 2010 | DOI: 10.1002/psc.1225
Yamamarin, a pentapeptide with an amidated C-terminus (DILRG-NH2), significantly suppresses the proliferation of rat hepatoma (liver cancer) cells. We investigated the structure– activity relationship of yamamarin by in vitro assay and spectroscopic methods (CD and NMR) for various analogs. We revealed that the structure -RG-NH2 is essential for cell growth suppression.