Convergent synthesis of a helical, prehairpin HR1 trimer from HIV gp41 (pages 465–472)
Rong Jian Lu, Catherine J. Mader, Stephen E. Schneider, Nicolai Tvermoes, Myung-Choi Kang, John J. Dwyer, Karen L. Wilson, Thomas J. Matthews, Mary K. Delmedico and Brian Bray
Article first published online: 13 JUL 2010 | DOI: 10.1002/psc.1262
A helical, prehairpin trimer covering the majority of the HR1 region of HIV gp41 was achieved by chemically coupling three identical 51 amino acid peptides using triacyl fluoride and orthogonal protection. The resulting protein is fully helical, highly thermostable and soluble.