A defensin-like antimicrobial peptide from the venoms of spider, Ornithoctonus hainana (pages 540–544)
Hongwen Zhao, Yi Kong, Hanjin Wang, Tianhua Yan, Feifei Feng, Jianmin Bian, Yan Yang and Haining Yu
Article first published online: 28 APR 2011 | DOI: 10.1002/psc.1370
A defensin-like antimicrobial peptide named Oh-defensin was purified and characterized from the venoms of the spider, Ornithoctonus hainana. Oh-defensin is composed of 52 amino acid residues including 6 cysteines that possibly form three disulfide bridges. Oh-defensin showed significant sequence similarity to other arthropod antimicrobial peptides of the defensin family. Oh-defensin exerted potent antimicrobial activities against tested microorganisms including Gram-positive bacteria, Gram-negative bacteria and fungi.