The insect peptide CopA3 inhibits lipopolysaccharide-induced macrophage activation (pages 650–656)
Hyo Jung Nam, Ah Reum Oh, Seung Taek Nam, Jin Ku Kang, Jong Soo Chang, Dae Hong Kim, Ji Hye Lee, Jae Sam Hwang, Ko Eun Shong, Mi Jung Park, Heon Seok and Ho Kim
Article first published online: 11 SEP 2012 | DOI: 10.1002/psc.2437
The α-helical domain of the natural insect peptide (coprisin) possesses antibacterial activity. We have synthesized a nine-mer dimeric D-type peptide (CopA3), derived from this domain, finding it to have anti-inflammatory activity against Clostridium difficile-induced animal colitis. Here, we report that CopA3 inhibits the LPS-induced activation of macrophages and that this inhibitory effect is associated with inactivation of JAK/STAT pathways involved in proinflammatory cytokine production. This suggests that CopA3 could be used against hyper-immune responses mediated by abnormally activated macrophages.