Journal of Peptide Science

Cover image for Vol. 18 Issue 11

November 2012

Volume 18, Issue 11

Pages 657–709

  1. Research Articles

    1. Top of page
    2. Research Articles
    1. Direct cell penetration of the antifungal peptide, MMGP1, in Candida albicans (pages 657–660)

      Muthuirulan Pushpanathan, Jeyaprakash Rajendhran, Sathyanarayanan Jayashree, Balakrishnan Sundarakrishnan, Seetharaman Jayachandran and Paramasamy Gunasekaran

      Version of Record online: 1 OCT 2012 | DOI: 10.1002/psc.2445

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      The cellular entry and cytotoxicity of newly identified MMGP1 antifungal peptide was studied in Candida albicans. The peptide enters the cells in a nondisruptive manner through energy-independent direct penetration mechanism and induces cytotoxicity in a time-dependent manner.

    2. Solid-phase synthesis and screening of a library of C-terminal arginine peptide aldehydes against Murray Valley encephalitis virus protease (pages 661–668)

      Nicholas J. Ede, Jeffrey Hill, Joma K. Joy, Anne-Marie Ede and Merran L. Koppens

      Version of Record online: 18 SEP 2012 | DOI: 10.1002/psc.2450

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      The solid-phase synthesis of a library of 400 C-terminal arginine peptide aldehydes and their screening against Murray Valley encephalitis virus protease are demonstrated. The library was utilised to elucidate several tripeptide sequences that can be used as inhibitors in further SAR studies.

    3. Epimerization in peptide thioester condensation (pages 669–677)

      Kenta Teruya, Takeyuki Tanaka, Toru Kawakami, Kenichi Akaji and Saburo Aimoto

      Version of Record online: 13 SEP 2012 | DOI: 10.1002/psc.2452

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      Epimerizations during the thioester peptide condensation and thioester exchange reaction were investigated under various conditions. The epimerization during segment condensation was significantly suppressed with a less polar solvent that is applicable to segments in thioester peptide condensation. These results were applied to a longer peptide thioester condensation. The epimer content was reduced from 27% to 6%.

    4. The crystal structure of samarosporin I at atomic resolution (pages 678–684)

      Renate Gessmann, Danny Axford, Gwyndaf Evans, Hans Brückner and Kyriacos Petratos

      Version of Record online: 28 SEP 2012 | DOI: 10.1002/psc.2454

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      The atomic resolution structures of the peptide antibiotic samarosporin I have been determined at 100 and 293 K. This is the first crystal structure of a natural 15-residue peptaibol. The amino acid sequence in samarosporin I is identical to emerimicin IV and stilbellin I. The structures at both temperatures are very similar to each other adopting mainly a 310-helical and a minor fraction of α-helical conformation.

    5. Stem cell recovering effect of copper-free GHK in skin (pages 685–690)

      Hye-Ryung Choi, Youn-A Kang, Sun-Jong Ryoo, Jung-Won Shin, Jung-Im Na, Chang-Hun Huh and Kyoung-Chan Park

      Version of Record online: 28 SEP 2012 | DOI: 10.1002/psc.2455

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      The Gly-His-Lys (GHK) is a naturally occurring tripeptide with affinity for copper(II) ions. The effects of copper-free GHK were investigated in skin equivalent models. Histological findings showed the basal cells were more cuboidal in GHK-treated models (hematoxylin and eosin). Immunohistochemical findings showed the expression of integrin β1 and the number of p63 positive cells significantly increased in response to treatment with GHK. Therefore, GHK increased the stemness and the proliferative potential of epidermal basal cells, which is associated with increased integrin expression.

    6. Structural analysis of the pyroglutamate-modified isoform of the Alzheimer's disease-related amyloid-β using NMR spectroscopy (pages 691–695)

      Na Sun, Rudolf Hartmann, Justin Lecher, Matthias Stoldt, Susanne Aileen Funke, Lothar Gremer, Hans-Henning Ludwig, Hans-Ulrich Demuth, Martin Kleinschmidt and Dieter Willbold

      Version of Record online: 24 SEP 2012 | DOI: 10.1002/psc.2456

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      NMR spectroscopy was performed to study the extremely aggregation-prone pE-Aβ3-40 in aqueous solution containing TFE. Proton resonances have been assigned for pE-Aβ3-40. Compared with the proton chemical shifts of Aβ1-40 under identical conditions, the pyroglutamate modification affects mainly the protons of amino-terminal residues. In comparison with Aβ1-40, pE-Aβ3-40 shows reduced helix propensities.

    7. Interaction of peptides spanning the transmembrane domain of caveolin-1 with model membranes (pages 696–703)

      Sowmya Bekshe Lokappa and Ramakrishnan Nagaraj

      Version of Record online: 1 OCT 2012 | DOI: 10.1002/psc.2457

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      The interaction of TM34, the caveolin-1 transmembrane sequence, with model membranes was investigated. A possible orientation of TM34 in the bilayer with Trp (in red) near the lipid headgroup region is depicted.

    8. S- to N-Acyl transfer in S-acylcysteine isopeptides via 9-, 10-, 12-, and 13-membered cyclic transition states (pages 704–709)

      Oleg Bol'shakov, Judit Kovacs, Mamta Chahar, Khanh Ha, Levan Khelashvili and Alan R. Katritzky

      Version of Record online: 12 OCT 2012 | DOI: 10.1002/psc.2438

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      The long-range S- to N-acyl migration via 9-, 10-, 12-, and 13-membered cyclic transition states to form native tripeptides and tetrapeptides analogs was studied on S-acylated cysteine-containing peptides. Experimental results are supported by structural and computational investigations.

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