Stem cell recovering effect of copper-free GHK in skin (pages 685–690)
Hye-Ryung Choi, Youn-A Kang, Sun-Jong Ryoo, Jung-Won Shin, Jung-Im Na, Chang-Hun Huh and Kyoung-Chan Park
Version of Record online: 28 SEP 2012 | DOI: 10.1002/psc.2455
The Gly-His-Lys (GHK) is a naturally occurring tripeptide with affinity for copper(II) ions. The effects of copper-free GHK were investigated in skin equivalent models. Histological findings showed the basal cells were more cuboidal in GHK-treated models (hematoxylin and eosin). Immunohistochemical findings showed the expression of integrin β1 and the number of p63 positive cells significantly increased in response to treatment with GHK. Therefore, GHK increased the stemness and the proliferative potential of epidermal basal cells, which is associated with increased integrin expression.